TWEAK/Fn14 promotes apoptosis of human endometrial cancer cells via caspase pathway

Wang, Dengfeng, Fung, Jenny Nga Ting Fung, Tuo, Ya, Hu, Lina and Chen, Chen (2010) TWEAK/Fn14 promotes apoptosis of human endometrial cancer cells via caspase pathway. Cancer Letters, 294 1: 91-100. doi:10.1016/j.canlet.2010.01.027

Author Wang, Dengfeng
Fung, Jenny Nga Ting Fung
Tuo, Ya
Hu, Lina
Chen, Chen
Title TWEAK/Fn14 promotes apoptosis of human endometrial cancer cells via caspase pathway
Journal name Cancer Letters   Check publisher's open access policy
ISSN 0304-3835
Publication date 2010-08-01
Sub-type Article (original research)
DOI 10.1016/j.canlet.2010.01.027
Volume 294
Issue 1
Start page 91
End page 100
Total pages 10
Editor D M Schwab
Place of publication Shannon, Ireland
Publisher Elsevier Ireland Ltd
Collection year 2011
Language eng
Subject C1
920102 Cancer and Related Disorders
060110 Receptors and Membrane Biology
1112 Oncology and Carcinogenesis
Abstract Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor fibroblast growth factor-inducible immediate-early response protein 14 (Fn14) have been detected in several human tumors, and demonstrated to regulate multiple cellular responses, including proliferation, survival, migration, apoptosis and differentiation, suggesting roles in cancer. The objective of this study was to clarify the role of TWEAK/Fn14 in the development of human endometrial cancer. We found that TWEAK gene expression was down-regulated and Fn14 gene expression was up-regulated in human endometrial cancer specimens compared with that in normal endometrial specimens; TWEAK acting on Fn14 decreased cell viability by inducing apoptosis through caspase pathways in endometrial cancer cells. Our results suggest that Fn14 expression is high in endometrial cancers whereas local produced TWEAK may be low. TWEAK/Fn14 pathway activation may promote cancer cell apoptosis, which provides a new therapeutic target for human endometrial cancer treatment. © 2010 Elsevier Ireland Ltd.
Keyword TWEAK
Endometrial cancer
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Biomedical Sciences Publications
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Created: Sun, 04 Jul 2010, 00:06:18 EST