Is velo-cardio-facial syndrome VCFS a useful model for understanding the genetics and pathogenesis of schizophrenia?

Catts, S. and Catts, V. (2007). Is velo-cardio-facial syndrome VCFS a useful model for understanding the genetics and pathogenesis of schizophrenia?. In: Peter Joyce, Abstracts from the WPA International Congress 2007. World Psychiatric Association International Congress 2007, Melbourne, Australia, (A474-A474). 28 November-2 December 2007. doi:10.1080/00048670701757092


Author Catts, S.
Catts, V.
Title of paper Is velo-cardio-facial syndrome VCFS a useful model for understanding the genetics and pathogenesis of schizophrenia?
Conference name World Psychiatric Association International Congress 2007
Conference location Melbourne, Australia
Conference dates 28 November-2 December 2007
Proceedings title Abstracts from the WPA International Congress 2007   Check publisher's open access policy
Place of Publication Melbourne, Australia
Publisher Informa Healthcare
Publication Year 2007
Year available 2007
Sub-type Poster
DOI 10.1080/00048670701757092
ISSN 0004-8674
1440-1614
Editor Peter Joyce
Volume 41
Issue Supp. 2
Start page A474
End page A474
Total pages 1
Language eng
Formatted Abstract/Summary
Introduction: There is dispute as to how closely psychotic disorder secondary to VCFS resembles schizophrenia.
Aim: To compare characteristics of VCFS-related psychotic disorder with those of schizophrenia.
Method: Literature review.
Results: The sex-ratio, age-of-onset distribution, premorbid precursors, symptom profile, neurocognitive correlates, pattern of dysmorphisms, and treatment response show similarity with schizophrenia. High levels of developmental comorbidity observed in VCFS (autistic spectrum and attention deficit disorder; and cardiac, endocrine and immunological abnormalities) are not apparent in schizophrenia. Most studies involve small sample sizes.
Conclusions: The 22q11.2 microdeletion causing VCFS may represent a specific genetic predisposition to schizophrenia, along with a broader group of developmental disorders. Availability of excellent mouse models of VCFS, eg the df1/ mouse, permits immediate neuroanatomical and molecular investigation of the associated pathogenesis.
Subjects 1117 Public Health and Health Services
Keyword Velo-Cardio-Facial Syndrome (VCFS)
Schizophrenia
VCFS-related psychotic disorder
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Poster # APP020.

Document type: Conference Paper
Collection: School of Medicine Publications
 
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Created: Thu, 01 Jul 2010, 11:32:34 EST by Ms Susana Macanawai on behalf of Faculty Of Health Sciences