Conopeptide characterization and classifications: An analysis using ConoServer

Kaas, Quentin, Westermann, Jan-Christoph and Craik, David J. (2010) Conopeptide characterization and classifications: An analysis using ConoServer. Toxicon, 55 8: 1491-1509. doi:10.1016/j.toxicon.2010.03.002

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Author Kaas, Quentin
Westermann, Jan-Christoph
Craik, David J.
Title Conopeptide characterization and classifications: An analysis using ConoServer
Journal name Toxicon   Check publisher's open access policy
ISSN 0041-0101
Publication date 2010-07
Sub-type Article (original research)
DOI 10.1016/j.toxicon.2010.03.002
Volume 55
Issue 8
Start page 1491
End page 1509
Total pages 19
Editor Alan L. Harvey
Place of publication Oxford, U.K
Publisher Elsevier Science
Collection year 2011
Language eng
Formatted abstract
Cone snails are carnivorous marine gastropods that have evolved potent venoms to capture their prey. These venoms comprise a rich and diverse cocktail of peptide toxins, or conopeptides, whose high diversity has arisen from an efficient hypermutation mechanism, combined with a high frequency of post-translational modifications. Conopeptides bind with high specificity to distinct membrane receptors, ion channels, and transporters of the central and muscular nervous system. As well as serving their natural function in prey capture, conopeptides have been utilized as versatile tools in neuroscience and have proven valuable as drug leads that target the nervous system in humans. This paper examines current knowledge on conopeptide sequences based on an analysis of gene and peptide sequences in ConoServer (, a specialized database of conopeptide sequences and three-dimensional structures. We describe updates to the content and organization of ConoServer and discuss correlations between gene superfamilies, cysteine frameworks, pharmacological families targeted by conopeptides, and the phylogeny, habitat, and diet of cone snails. The study identifies gaps in current knowledge of conopeptides and points to potential directions for future research.
© 2010 Elsevier Ltd.
Keyword Conus venom
Cone snail venom
Nicotinic acetylcholine-receptor
Conus-geographus venom
Channel-blocking conotoxins
Unique cysteine pattern
Gastropod genus conus
Superfamily conotoxins
Marine gastropod
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
Institute for Molecular Bioscience - Publications
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Citation counts: TR Web of Science Citation Count  Cited 81 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 27 Jun 2010, 00:00:37 EST