Extrapulmonary tissue responses in cynomolgus macaques (Macaca fascicularis) infected with highly pathogenic avian influenza A (H5N1) virus

Tolnay, A. E., Baskin, C. R., Tumpey, T. M., Sabourin, P. J., Sabourin, C. L., Long, J. P., Pyles, J. A., Albrecht, R. A., Garcia-Sastre, A., Katze, M. G. and Bielefeldt-Ohmann, H. (2010) Extrapulmonary tissue responses in cynomolgus macaques (Macaca fascicularis) infected with highly pathogenic avian influenza A (H5N1) virus. Archive of Virology, 155 6: 905-914. doi:10.1007/s00705-010-0662-8


Author Tolnay, A. E.
Baskin, C. R.
Tumpey, T. M.
Sabourin, P. J.
Sabourin, C. L.
Long, J. P.
Pyles, J. A.
Albrecht, R. A.
Garcia-Sastre, A.
Katze, M. G.
Bielefeldt-Ohmann, H.
Title Extrapulmonary tissue responses in cynomolgus macaques (Macaca fascicularis) infected with highly pathogenic avian influenza A (H5N1) virus
Formatted title
Extrapulmonary tissue responses in cynomolgus macaques (Macaca fascicularis) infected with highly pathogenic avian influenza A (H5N1) virus
Journal name Archive of Virology   Check publisher's open access policy
ISSN 0304-8608
1432-8798
Publication date 2010-06
Sub-type Article (original research)
DOI 10.1007/s00705-010-0662-8
Volume 155
Issue 6
Start page 905
End page 914
Total pages 10
Place of publication Vienna, Austria
Publisher Springer Wien
Collection year 2011
Language eng
Subject 07 Agricultural and Veterinary Sciences
Formatted abstract
The mechanisms responsible for virulence of influenza viruses in humans remain poorly understood. A prevailing hypothesis is that the highly pathogenic virus isolates cause a severe cytokinemia precipitating acute respiratory distress syndrome and multiple organ dysfunction syndrome. Cynomolgus macaques (Macaca fascicularis) infected with a human highly pathogenic avian influenza (HPAI) H5N1 virus isolate (A/Vietnam/1203/2004) or reassortants of human influenza virus A/Texas/36/91 (H1N1) containing genes from the 1918 pandemic influenza A (H1N1) virus developed severe pneumonia within 24 h postinfection. However, virus spread beyond the lungs was only detected in the H5N1 group, and signs of extrapulmonary tissue reactions, including microglia activation and sustained up-regulation of inflammatory markers, most notably hypoxia inducible factor-1α (HIF-1α), were largely limited to this group. Extrapulmonary pathology may thus contribute to the morbidities induced by H5N1 viruses. © 2010 Springer-Verlag.
Keyword Activated Protein-Kinase
Necrosis-Factor-Alpha
Necrotizing Encephalopathy
Respiratory-Tract
Immune-Response
Humans
Pathology
Expression
Disease
Spread
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Veterinary Science Publications
 
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Created: Sun, 20 Jun 2010, 00:08:16 EST