Being born small programs impaired glucose tolerance in pregnancy

Wlodek, Mary E., Tran, Melanie, Westcott, Kerryn T., Jefferies, Andrew, Gallo, Linda A. and Moritz, Karen M. (2010). Being born small programs impaired glucose tolerance in pregnancy. In: 57th Annual Meeting of the Society for Gynecologic Investigation, Orlando, FL, U.S.A., (314A-314A). 24-27 March 2010. doi:10.1177/193371912010173s067

Author Wlodek, Mary E.
Tran, Melanie
Westcott, Kerryn T.
Jefferies, Andrew
Gallo, Linda A.
Moritz, Karen M.
Title of paper Being born small programs impaired glucose tolerance in pregnancy
Conference name 57th Annual Meeting of the Society for Gynecologic Investigation
Conference location Orlando, FL, U.S.A.
Conference dates 24-27 March 2010
Journal name Reproductive Sciences   Check publisher's open access policy
Place of Publication Thousand Oaks, CA, U.S.A.
Publisher Sage Publications
Publication Year 2010
Year available 2010
Sub-type Poster
DOI 10.1177/193371912010173s067
ISSN 1933-7191
Volume 17
Issue 3, Supp. 1
Start page 314A
End page 314A
Total pages 1
Collection year 2011
Language eng
Formatted Abstract/Summary
Fetal growth restriction, induced by uteroplacental insufficiency, alters insulin sensitivity but not glucose tolerance in 6 month old females. Metabolic adaptations to pregnancy may be altered in females born small influencing fetal growth and development. Our aim was to investigate the effects of being born small on glucose tolerance and insulin secretion in non pregnant and pregnant female rats. Uteroplacental insufficiency was induced by bilateral uterine vessel ligation (Restricted) or sham surgery (Control) on day 18 of pregnancy in WKY rats. Control and Restricted non pregnant female offspring were studied at 4 months. Another cohort of Control and Restricted offspring were mated with a normal male at 4 months and studied during pregnancy. Non pregnant and pregnant (day 18) females underwent an intraperitoneal glucose tolerance test (IPGTT, 1g/kg). Blood samples for measurement of plasma glucose and insulin concentrations were collected via tail slice before and to 90 min after glucose. Post mortem was performed 2 days after IPGTT in pregnant and 2-7 days (in estrus) in non pregnant females. Restricted females were born 12-15% smaller compared to Control (p<0.05). Body weight and pancreas, uterine and ovarian weights were not different between Control and Restricted in non pregnant and pregnant females with no differences in maternal food intake between groups. In the Restricted females, fetal weight on day 20 of pregnancy was 5% lower than Controls (p<0.05). In non pregnant females, no differences were detected in plasma glucose or insulin responses to IPGTT between groups. In pregnancy, Restricted females had a higher peak glucose (+16%) and greater area under glucose curve (+36%) compared to Control (p<0.05) with no differences in basal glucose or insulin concentrations. Insulin response to IPGTT and area under insulin curve was not different between groups during pregnancy. Our data demonstrates that growth restricted offspring develop impaired glucose tolerance during pregnancy but not in the non pregnant state. This suggests that the altered metabolic profi le during pregnancy may influence growth and development of the next generation.
Copyright © 2011 by Society fo Gynecologic Investigation

Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Abstract number 862.

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Created: Sun, 20 Jun 2010, 00:01:30 EST