Protocol for a randomised controlled trial investigating the effectiveness of an online e-health application compared to attention placebo or sertraline in the treatment of generalised anxiety disorder

Christensen, Helen, Guastella, Adam J., Mackinnon, Andrew J., Griffiths, Kathleen M., Eagleson, Claire, Batterham, Philip J., Kalia, Kanupriya, Kenardy, Justin, Bennett, Kylie and Hickie, Ian B. (2010) Protocol for a randomised controlled trial investigating the effectiveness of an online e-health application compared to attention placebo or sertraline in the treatment of generalised anxiety disorder. Trials, 11 48: 1-8. doi:10.1186/1745-6215-11-48


Author Christensen, Helen
Guastella, Adam J.
Mackinnon, Andrew J.
Griffiths, Kathleen M.
Eagleson, Claire
Batterham, Philip J.
Kalia, Kanupriya
Kenardy, Justin
Bennett, Kylie
Hickie, Ian B.
Title Protocol for a randomised controlled trial investigating the effectiveness of an online e-health application compared to attention placebo or sertraline in the treatment of generalised anxiety disorder
Journal name Trials   Check publisher's open access policy
ISSN 1745-6215
1468-6694
Publication date 2010-04-30
Sub-type Article (original research)
DOI 10.1186/1745-6215-11-48
Open Access Status DOI
Volume 11
Issue 48
Start page 1
End page 8
Total pages 8
Editor Curt Furberg
Doug Altman
Jeremy Grimshaw
Place of publication London, U.K.
Publisher BioMed Central
Collection year 2011
Language eng
Formatted abstract
Background: Generalised anxiety disorder (GAD) is a high prevalence, chronic psychiatric disorder which commonly presents early in the lifespan. Internet e-health applications have been found to be successful in reducing symptoms of anxiety and stress for post traumatic stress disorder (PTSD), panic disorder, social phobia and depression. However, to date, there is little evidence for the effectiveness of e-health applications in adult GAD. There are no studies which have directly compared e-health applications with recognised evidence-based medication. This study aims to determine the effectiveness of a web-based program for treating GAD relative to sertraline and attention placebo.

Methods/Design: 120 community-dwelling participants, aged 18-30 years with a clinical diagnosis of GAD will be recruited from the Australian Electoral Roll. They will be randomly allocated to one of three conditions: (i) an online treatment program for GAD, E-couch (ii) pharmacological treatment with a selective serotonin re-uptake inhibitor (SSRI), sertraline (a fixed-flexible dose of 25-100 mg/day) or (iii) an attention control placebo, HealthWatch. The treatment program will be completed over a 10 week period with a 12 month follow-up.

Discussion: As of February 2010, there were no registered trials evaluating the effectiveness of an e-health application for GAD for young adults. Similarly to date, this will be the first trial to compare an e-health intervention with a
pharmacological treatment.

Trial Registration: Current Controlled Trials ISRCTN76298775
© 2010 Christensen et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Keyword Cognitive-behavioral therapy
International neuropsychiatric interview
Internet-based treatment
Childhood anxiety
Social phobia
Primary-care
PRIME-MD
DSM-IV
Validation
Depression
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Medicine Publications
 
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Created: Sun, 20 Jun 2010, 00:00:48 EST