Cottontail rabbit papillomavirus in Langerhans cells in Sylvilagus spp.

Weiner, C. M., Rosenbaum, M. D., Fox, K., Mason, G., Bielefeldt-Ohmann, H., Veeramachaneni, D. N. R. and Vandewoude, S. (2010) Cottontail rabbit papillomavirus in Langerhans cells in Sylvilagus spp.. Journal of Veterinary Diagnostic Investigation, 22 3: 451-454.

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Name Description MIMEType Size Downloads
Author Weiner, C. M.
Rosenbaum, M. D.
Fox, K.
Mason, G.
Bielefeldt-Ohmann, H.
Veeramachaneni, D. N. R.
Vandewoude, S.
Title Cottontail rabbit papillomavirus in Langerhans cells in Sylvilagus spp.
Journal name Journal of Veterinary Diagnostic Investigation   Check publisher's open access policy
ISSN 1040-6387
Publication date 2010-05
Sub-type Article (original research)
Volume 22
Issue 3
Start page 451
End page 454
Total pages 4
Place of publication Thousand Oaks, CA, United States
Publisher Sage Publications
Collection year 2011
Language eng
Subject 07 Agricultural and Veterinary Sciences
Abstract A wildlife sanctuary presented an adult female cottontail rabbit (Sylvilagus spp.), age unknown, to the Colorado State University Pathology service for postmortem examination. Gross examination revealed numerous pigmented wartlike lesions arising from the skin of the head surrounding the ears, eyes, nares, mouth, and dorsum. Masses were firm, friable, and easily detached from the underlying skin. Differential diagnoses included Cottontail rabbit papillomavirus, Rabbit fibroma virus, and Myxoma virus. Histological examination revealed multiple papillary masses lined by stratified squamous epithelial cells with central cores of fibrovascular connective tissue and parakeratotic hyperkeratosis. Cells of the Stratum spinosum were frequently swollen with abundant perinuclear, cytoplasmic, clearing, and occasional intranuclear basophilic, glassy, spherical inclusions up to 3 μm in diameter. The lesions were consistent with Cottontail rabbit papillomavirus infection. Papilloma virus antigens were identified by immunohistochemistry. In addition, papillomavirus particles were identified by transmission electron microscopy within Langerhans cells of the epidermis, suggesting a unique mechanism for systemic dissemination of the virus. The present case report highlights the finding of viral particles within the Langerhans cells and suggests a novel mechanism of pathogenesis. Copyright © 2010 by the American Association of Veterinary Laboratory Diagnosticians, Inc.
Keyword Cottontail rabbit papillomavirus
Langerhans cells
Sylvilagus spp.
transmission electron microscopy
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Veterinary Science Publications
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Created: Sun, 13 Jun 2010, 00:02:27 EST