Broome virus, a new fusogenic Orthoreovirus species isolated from an Australian fruit bat

Thalmann, Claudia M., Cummins, David Michael, Yu, Meng, Lunt, Ross, Pritchard, Lindsay Ian, Hansson, Eric, Crameri, Sandra, Hyatt, Alex and Wang, Lin-Fa (2010) Broome virus, a new fusogenic Orthoreovirus species isolated from an Australian fruit bat. Virology, 402 1: 26-40. doi:10.1016/j.virol.2009.11.048


Author Thalmann, Claudia M.
Cummins, David Michael
Yu, Meng
Lunt, Ross
Pritchard, Lindsay Ian
Hansson, Eric
Crameri, Sandra
Hyatt, Alex
Wang, Lin-Fa
Title Broome virus, a new fusogenic Orthoreovirus species isolated from an Australian fruit bat
Formatted title
Broome virus, a new fusogenic Orthoreovirus species isolated from an Australian fruit bat
Journal name Virology   Check publisher's open access policy
ISSN 0042-6822
1089-862X
1096-0341
Publication date 2010-06-20
Sub-type Article (original research)
DOI 10.1016/j.virol.2009.11.048
Volume 402
Issue 1
Start page 26
End page 40
Total pages 15
Place of publication Maryland Heights, MO, U.S.A.
Publisher Academic Press
Collection year 2011
Language eng
Formatted abstract
This report describes the discovery and characterization of a new fusogenic orthoreovirus, Broome virus (BroV), isolated from a little red flying-fox (Pteropus scapulatus). The BroV genome consists of 10 dsRNA segments, each having a 3′ terminal pentanucleotide sequence conserved amongst all members of the genus Orthoreovirus, and a unique 5′ terminal pentanucleotide sequence. The smallest genome segment is bicistronic and encodes two small nonstructural proteins, one of which is a novel fusion associated small transmembrane (FAST) protein responsible for syncytium formation, but no cell attachment protein. The low amino acid sequence identity between BroV proteins and those of other orthoreoviruses (13–50%), combined with phylogenetic analyses of structural and nonstructural proteins provide evidence to support the classification of BroV in a new sixth species group within the genus Orthoreovirus.
© 2009 Elsevier Inc.

Keyword Broome virus
Fusogenic orthoreovirus
Flying-fox
Bat
FAST protein
Small nonstructural proteins
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Chemistry and Molecular Biosciences
 
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Created: Sun, 13 Jun 2010, 00:00:22 EST