Newly identified human rhinoviruses: Molecular methods heat up the cold viruses

Arden, Katherine E. and Mackay, Ian M. (2010) Newly identified human rhinoviruses: Molecular methods heat up the cold viruses. Reviews In Medical Virology, 20 3: 156-176. doi:10.1002/rmv.644

Author Arden, Katherine E.
Mackay, Ian M.
Title Newly identified human rhinoviruses: Molecular methods heat up the cold viruses
Journal name Reviews In Medical Virology   Check publisher's open access policy
ISSN 1052-9276
Publication date 2010-05
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/rmv.644
Volume 20
Issue 3
Start page 156
End page 176
Total pages 21
Place of publication West Sussex, United Kingdom
Publisher John Wiley & Sons
Collection year 2011
Language eng
Formatted abstract
Human rhinovirus (HRV) infections cause at least 70% of virus-related wheezing exacerbations and cold and flu-like
illnesses. They are associated with otitis media, sinusitis and pneumonia. Annually, the economic impact of HRV
infections costs billions in healthcare and lost productivity. Since 1987, 100 officially recognised HRV serotypes reside
in two genetically distinct species; HRV A and HRV B, within the genus Enterovirus, family Picornaviridae. Sequencing
of their ~ 7kb genomes was finalised in 2009. Since 1999, many globally circulating, molecularly-defined ‘strains’,
perhaps equivalent to novel serotypes, have been discovered but remain uncharacterised. Many of these currently
unculturable strains have been assigned to a proposed new species, HRV C although confusion exists over the
membership of the species. There has not been sufficient sampling to ensure the identification of all strains and no
consensus criteria exist to define whether clinical HRV detections are best described as a distinct strain or a closely
related variant of a previously identified strain (or serotype). We cannot yet robustly identify patterns in the circulation
of newly identified HRVs (niHRVs) or the full range of associated illnesses and more data are required. Many
questions arise from this new found diversity: what drives the development of so many distinct viruses compared to
other species of RNA viruses? What role does recombination play in generating this diversity? Are there species- or
strain-specific circulation patterns and clinical outcomes? Are divergent strains sensitive to existing capsid-binding
antivirals? This update reviews the findings that trigger these and other questions arising during the current cycle of
intense rhinovirus discovery. Copyright © 2010 John Wiley & Sons, Ltd.
Keyword Respiratory-tract infections
Reverse transcription-PCR
Complete nucleotide-sequence
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Erratum: Newly identified human rhinoviruses: molecular methods heat up the cold viruses Volume 20, Issue 6, November 2010, Page 408 DOI: 10.1002/rmv.669

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2011 Collection
Clinical Medical Virology Centre Publications
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Created: Sun, 06 Jun 2010, 00:01:34 EST