Metabolic factors and non-alcoholic fatty liver disease as co-factors in other liver diseases

Powell, Elizabeth E., Jonsson, Julie R. and Clouston, Andrew D. (2010). Metabolic factors and non-alcoholic fatty liver disease as co-factors in other liver diseases. In: C. P. Day, A. M. Diehl, H. Lehnert, M. P. Manns and F. Negro, Proceedings of: Falk Liver Conference. Falk Workshop 2009: Immunology and Liver Disease. Falk Symposium 171: Liver and Metabolic Syndrome. Falk Symposium 171 on Liver and Metabolic Syndrome, Hannover, Germany, (186-191). 15-18 October 2009. doi:10.1159/000282084


Author Powell, Elizabeth E.
Jonsson, Julie R.
Clouston, Andrew D.
Title of paper Metabolic factors and non-alcoholic fatty liver disease as co-factors in other liver diseases
Conference name Falk Symposium 171 on Liver and Metabolic Syndrome
Conference location Hannover, Germany
Conference dates 15-18 October 2009
Proceedings title Proceedings of: Falk Liver Conference. Falk Workshop 2009: Immunology and Liver Disease. Falk Symposium 171: Liver and Metabolic Syndrome   Check publisher's open access policy
Journal name Digestive Diseases   Check publisher's open access policy
Place of Publication Basel, Switzerland
Publisher S. Karger AG
Publication Year 2010
Year available 2009
Sub-type Fully published paper
DOI 10.1159/000282084
ISBN 9783805594257
3805594259
ISSN 0257-2753
1421-9875
Editor C. P. Day
A. M. Diehl
H. Lehnert
M. P. Manns
F. Negro
Volume 28
Issue 1
Start page 186
End page 191
Total pages 6
Collection year 2011
Language eng
Formatted Abstract/Summary
Over the last few years, the paradigm in hepatology has changed from focusing on a single liver disease to considering concurrent diseases, in particular obesity and related metabolic factors. Obesity has reached epidemic proportions globally and is associated with insulin resistance, steatosis and a low-grade systemic inflammatory state. These metabolic factors have a synergistic role in the natural history and treatment outcomes related to chronic liver disease. This is characterized best in chronic hepatitis C where steatosis and insulin resistance are caused by viral and metabolic effects. Non-alcoholic fatty liver disease and related metabolic abnormalities also exacerbate other diseases, such as alcoholic liver disease and haemochromatosis. In addition, there is growing evidence linking obesity and type 2 diabetes with hepatocellular carcinoma in subjects with chronic viral hepatitis. The pathogenesis of co-morbid disease may be related to increased oxidative stress, inflammatory injury and cell death, along with altered hepatocyte regeneration and repair. Hyperinsulinaemia and other metabolic factors may also have a direct role in the progression of liver injury. Data indicate that weight reduction improves steatosis and inflammation in patients with chronic hepatitis C. This has important clinical and therapeutic implications and suggests that obesity should be actively addressed in the management of patients with other chronic liver diseases.
Copyright © 2010 S. Karger AG, Basel
Subjects 110312 Nephrology and Urology
Keyword Obesity
Insulin resistance
Hepatitis C
Chronic Hepatitis C
Alanine aminotransferase
Overweight Patients
Risk factors
Steatosis
Fibrosis
Prevalence
Hemochromatosis
Cirrhosis
Insulin
Q-Index Code EX
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Conference Paper
Collections: Non HERDC
ERA 2012 Admin Only
School of Medicine Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 16 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 18 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 30 May 2010, 00:06:17 EST