Latent class piecewise linear trajectory modelling for short-term cognition responses after chemotherapy for breast cancer patients

Rolfe, M. I., Mengersen, K., Beadle, G., Vearncombe, K., Andrew, B., Johnson, H. L. and Walsh, C. (2010) Latent class piecewise linear trajectory modelling for short-term cognition responses after chemotherapy for breast cancer patients. Journal of Applied Statistics, 37 5: 725-738. doi:10.1080/02664760902729641


Author Rolfe, M. I.
Mengersen, K.
Beadle, G.
Vearncombe, K.
Andrew, B.
Johnson, H. L.
Walsh, C.
Title Latent class piecewise linear trajectory modelling for short-term cognition responses after chemotherapy for breast cancer patients
Journal name Journal of Applied Statistics   Check publisher's open access policy
ISSN 0266-4763
1360-0532
Publication date 2010-05
Sub-type Article (original research)
DOI 10.1080/02664760902729641
Volume 37
Issue 5
Start page 725
End page 738
Total pages 14
Place of publication Abingdon, Oxon, United Kingdom
Publisher Routledge
Collection year 2011
Language eng
Abstract This paper investigates the impact of chemotherapy on cognitive function of breast cancer patients and whether this response is homogeneous for all patients. Latent class piecewise linear trajectory (growth) models were employed to describe changes and identify subgroups in three Auditory Verbal Learning Test measures (learning, immediate retention and delayed recall) in 130 breast cancer patients taken at three time periods: before chemotherapy and 1 and 6 months post-chemotherapy. Two distinct subgroups of women exhibiting different patterns of response were identified for learning and delayed recall and three for immediate retention. The groups differed in level (intercept) at 1 month post-chemotherapy and patterns of decline and recovery. Binomial and multinomial logistic regressions on the latent classes found that age, initial National Adult Reading Test (NART)-predicted IQ, stage of cancer and the initial Functional Assessment of Cancer Therapy-Breast subscale (or subsets thereof) to be significant predictors of classes. © 2010 Taylor & Francis.
Keyword Latent class
Piecewise linear
Trajectory
Cognition
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Psychology Publications
 
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Created: Sun, 30 May 2010, 00:03:59 EST