Evaluation of the Becton-Dickinson rapid serum tube: Does it provide a suitable alternative to lithium heparin plasma tubes?

Dimeski, G, Masci, PP, Trabi, M, Lavin, MF and de Jersey, J (2010) Evaluation of the Becton-Dickinson rapid serum tube: Does it provide a suitable alternative to lithium heparin plasma tubes?. Clinical Chemistry and Laboratory Medicine, 48 5: 651-657. doi:10.1515/CCLM.2010.141

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Author Dimeski, G
Masci, PP
Trabi, M
Lavin, MF
de Jersey, J
Title Evaluation of the Becton-Dickinson rapid serum tube: Does it provide a suitable alternative to lithium heparin plasma tubes?
Journal name Clinical Chemistry and Laboratory Medicine   Check publisher's open access policy
ISSN 1434-6621
1437-4331
Publication date 2010-05-01
Sub-type Article (original research)
DOI 10.1515/CCLM.2010.141
Open Access Status File (Publisher version)
Volume 48
Issue 5
Start page 651
End page 657
Total pages 7
Place of publication Berlin, Germany
Publisher Walter de Gruyter
Collection year 2011
Language eng
Formatted abstract
Background: Obtaining a suitable specimen for analysis in a timely manner is pivotal in clinical chemistry service provision. Serum is recognized as the preferred specimen for most assays, but because of time constraints for completion of clotting and an increasing number of patients on anti-coagulant therapy, latent clotting or no clotting is an outcome which can lead to errors and delay in delivery of critical results. Although lithium heparin plasma has unique problems, it has become an alternative in hospital-based laboratories.
Methods: The Becton-Dickinson (BD) rapid serum tube (RST) was evaluated in a hospital environment using a total of 53 participants, both healthy and anticoagulated, for 31 analytes against BD PST II and BD SST II tubes measured with Beckman DxC800 and DxI800 analyzers.
Results: Most results from the RST tube were comparable with those from the SST II tube. Potassium results were closer to the PST II plasma concentrations. Incomplete and latent clotting was encountered in the RST specimens from participants (cardiac and dialysis) who had received a total of >7000 units of heparin [activated partial thromboplastin time (APTT) >150 s], warfarin/heparin combination, and specimens from cardiac surgery patients who had received a total of >25, 000 units of heparin (APTT >200 s) at the time of collection of specimens.
Conclusions: The RST tube provides a suitable alternative to lithium heparin plasma tubes for most patients in a hospital environment. However, latent clotting continued to occur in specimens collected from participants who had received high concentrations of anticoagulants.
© 2010 by Walter de Gruyter Berlin New York.
Keyword Anticoagulants
Latent clotting
Plasma
Rapid serum tube
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Sun, 23 May 2010, 00:05:26 EST