Differential gene expression identified in Uigur women cervical squamous cell carcinoma by suppression subtractive hybridization

Pan, Z, Chen, S, Pan, X, Wang, Z, Han, H, Zheng, W, Wang, X, Li, F, Qu, S and Shao, R (2010) Differential gene expression identified in Uigur women cervical squamous cell carcinoma by suppression subtractive hybridization. Neoplasma, 57 2: 123-128. doi:10.4149/neo_2010_02_123

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Author Pan, Z
Chen, S
Pan, X
Wang, Z
Han, H
Zheng, W
Wang, X
Li, F
Qu, S
Shao, R
Title Differential gene expression identified in Uigur women cervical squamous cell carcinoma by suppression subtractive hybridization
Journal name Neoplasma   Check publisher's open access policy
ISSN 0028-2685
Publication date 2010
Sub-type Article (original research)
DOI 10.4149/neo_2010_02_123
Volume 57
Issue 2
Start page 123
End page 128
Total pages 6
Place of publication Bratislava, Slovakia
Publisher Vydavatel'stvo Slovenskej Akademie Vied Veda
Collection year 2011
Language eng
Abstract Cervical cancer is one of the most common gynecological cancers worldwide. Over the past decade, much progress has been made in understanding the genetic changes associated with the development and progression of cervical cancer. However, the precise mechanisms of cervical carcinogenesis in Uigur women remain unclear. To screen differential gene expression in squamous cell carcinoma (SCC) of the cervix in Uigur women, suppressive subtractive hybridization (SSH) was performed on the cervical squamous cell carcinoma and corresponding normal cervical tissues of a Uigur patient. Thus we were be able to find the genes that are related with cervical tumors of Uigur women. A total of 300 samples were subject to DNA sequencing analysis and 46 genes were found to express differentially in tumors compared with normal tissues. Of the 46 genes, 24 genes were up-regulated whereas 22 genes were down-regulated in cervical tumors. The expression profiles of 5 of the 46 genes were further confirmed in 15 other Uigur patients by semi-quantitative reverse-transcription polymerase chain reaction. Our results revealed that ACADVL, CEBPB, IFITM1 and DNAJC9 are involved in cervical carcinogenesis.
Keyword Uigur women squamous cell carcinoma
suppression subtractive hybridization
gene expression
cervical tumor
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Chemistry and Molecular Biosciences
 
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Citation counts: TR Web of Science Citation Count  Cited 15 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 23 May 2010, 00:01:55 EST