Pseudoephedrine ingestion and cycling time-trial performance

Pritchard-Peschek, Kellie R., Jenkins, David G., Osborne, Mark A. and Slater, Gary J. (2010) Pseudoephedrine ingestion and cycling time-trial performance. International Journal of Sport Nutrition and Exercise Metabolism, 20 2: 132-138.

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Author Pritchard-Peschek, Kellie R.
Jenkins, David G.
Osborne, Mark A.
Slater, Gary J.
Title Pseudoephedrine ingestion and cycling time-trial performance
Journal name International Journal of Sport Nutrition and Exercise Metabolism   Check publisher's open access policy
ISSN 1526-484X
Publication date 2010-04
Sub-type Article (original research)
Volume 20
Issue 2
Start page 132
End page 138
Total pages 7
Place of publication Champaign, IL, U.S.A.
Publisher Human Kinetics
Collection year 2011
Language eng
Formatted abstract
The aim of the current study was to investigate the effect of 180 mg of pseudoephedrine (PSE) on cycling time-trial (TT) performance. Six well-trained male cyclists and triathletes (age 33 ± 2 yr, mass 81 ± 8 kg, height 182.0 ± 6.7 cm, VO2max 56.8 ± 6.8 ml · kg–1 · min–1; ± SD) underwent 2 performance trials in which they completed a 25-min variable-intensity (50–90% maximal aerobic power) warm-up, followed by a cycling TT in which they completed a fixed amount of work (7 kJ/kg body mass) in the shortest possible time. Sixty minutes before the start of exercise, they orally ingested 180 mg of PSE or a cornstarch placebo (PLA) in a randomized, crossover, double-blind manner. Venous blood was sampled immediately pre- and postexercise for the analysis of pH plus lactate, glucose, and norepinephrine (NE). PSE improved cycling TT performance by 5.1% (95% CI 0–10%) compared with PLA (28:58.9 ± 4:26.5 and 30:31.7 ± 4:36.7 min, respectively). There was a significant Treatment × Time interaction (= .04) for NE, with NE increasing during the PSE trial only. Similarly, blood glucose also showed a trend (= .06) for increased levels postexercise in the PSE trial. The ingestion of 180 mg of PSE 60 min before the onset of high-intensity exercise improved cycling TT performance in well-trained athletes. It is possible that changes in metabolism or an increase in central nervous system stimulation is responsible for the observed ergogenic effect of PSE.
© 2010 Human Kinetics, Inc.
Keyword Sympathomimetic
Ergogenic aid
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Human Movement and Nutrition Sciences Publications
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Created: Sun, 16 May 2010, 00:04:57 EST