ImmunoGrid: Towards agent-based simulations of the human immune system at a natural scale

Halling-Brown, Mark, Pappalardo, Francesco, Rapin, Nicolas, Zhang, Ping, Alemani, David, Emerson, Andrew, Castiglione, Filippo, Duroux, Patrice, Pennisi, Marzio, Miotto, Olivo, Churchill, Daniel, Rossi, Elda, Moss, David S., Sansom, Clare E., Bernaschi, Massimo, Lefranc, Marie-Paule, Brunak, Soren, Lund, Ole, Motta, Santo, Lollini, Pier-Luigi, Murgo, Annalisa, Palladini, Arianna, Basford, Kaye E., Brusic, Vladimir and Shepherd, Adrian J. (2010). ImmunoGrid: Towards agent-based simulations of the human immune system at a natural scale. In: Marco Viceconti and Peter Kohl, 4th International Congress on Computational Bioengineering/1st European Symposium on Biomedical Integrative Research, Bertinoro, Italy, (2799-2815). 16-18 September 2009. doi:10.1098/rsta.2010.0067

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ205217_Combined.pdf HERDC Combined - not publicly available application/pdf 1.02MB 3

Author Halling-Brown, Mark
Pappalardo, Francesco
Rapin, Nicolas
Zhang, Ping
Alemani, David
Emerson, Andrew
Castiglione, Filippo
Duroux, Patrice
Pennisi, Marzio
Miotto, Olivo
Churchill, Daniel
Rossi, Elda
Moss, David S.
Sansom, Clare E.
Bernaschi, Massimo
Lefranc, Marie-Paule
Brunak, Soren
Lund, Ole
Motta, Santo
Lollini, Pier-Luigi
Murgo, Annalisa
Palladini, Arianna
Basford, Kaye E.
Brusic, Vladimir
Shepherd, Adrian J.
Title of paper ImmunoGrid: Towards agent-based simulations of the human immune system at a natural scale
Conference name 4th International Congress on Computational Bioengineering/1st European Symposium on Biomedical Integrative Research
Conference location Bertinoro, Italy
Conference dates 16-18 September 2009
Journal name Royal Society of London. Philosophical Transactions A. Mathematical, Physical and Engineering Sciences   Check publisher's open access policy
Place of Publication London, U.K.
Publisher Royal Society
Publication Year 2010
Sub-type Fully published paper
DOI 10.1098/rsta.2010.0067
ISSN 1364-503X
1471-2962
Editor Marco Viceconti
Peter Kohl
Volume 368
Issue 1920
Start page 2799
End page 2815
Total pages 17
Collection year 2011
Language eng
Abstract/Summary The ultimate aim of the EU-funded ImmunoGrid project is to develop a natural-scale model of the human immune system-that is, one that reflects both the diversity and the relative proportions of the molecules and cells that comprise it-together with the grid infrastructure necessary to apply this model to specific applications in the field of immunology. These objectives present the ImmunoGrid Consortium with formidable challenges in terms of complexity of the immune system, our partial understanding about how the immune system works, the lack of reliable data and the scale of computational resources required. In this paper, we explain the key challenges and the approaches adopted to overcome them. We also consider wider implications for the present ambitious plans to develop natural-scale, integrated models of the human body that can make contributions to personalized health care, such as the European Virtual Physiological Human initiative. Finally, we ask a key question: How long will it take us to resolve these challenges and when can we expect to have fully functional models that will deliver health-care benefits in the form of personalized care solutions and improved disease prevention? This journal is © 2010 The Royal Society.
Keyword Systems biology
Agent-based simulation
Immunoinformatics
Grid computing
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 18 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 22 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sun, 16 May 2010, 00:02:08 EST