Silibinin - A promising new treatment for cancer

Cheung, Catherine Wing Ying, Gibbons, Norma, Johnson, David Wayne and Nicol, David Lawrence (2010) Silibinin - A promising new treatment for cancer. Anti-Cancer Agents in Medicinal Chemistry, 10 3: 186-195.

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Name Description MIMEType Size Downloads
Author Cheung, Catherine Wing Ying
Gibbons, Norma
Johnson, David Wayne
Nicol, David Lawrence
Title Silibinin - A promising new treatment for cancer
Journal name Anti-Cancer Agents in Medicinal Chemistry   Check publisher's open access policy
ISSN 1871-5206
Publication date 2010-03
Sub-type Article (original research)
Volume 10
Issue 3
Start page 186
End page 195
Total pages 10
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Collection year 2011
Language eng
Abstract Silymarin and its major constituent, Silibinin, are extracts from the medicinal plant Silybum marianum (milk thistle) and have traditionally been used for the treatment of liver diseases. Recently, these orally active, flavonoid agents have also been shown to exert significant anti-neoplastic effects in a variety of in vitro and in vivo cancer models, including skin, breast, lung, colon, bladder, prostate and kidney carcinomas. The aim of the present review is to examine the pharmacokinetics, mechanisms, effectiveness and adverse effects of silibinin's anti-cancer actions reported to date in pre-clinical and clinical trials. The review will also discuss the results of current research efforts seeking to determine the extent to which the effectiveness of silibinin as an adjunct cancer treatment is influenced by such factors as histologic subtype, hormonal status, stromal interactions and drug metabolising gene polymorphisms. The results of these studies may help to more precisely target and dose silibinin therapy to optimise clinical outcomes for oncology patients. © 2010 Bentham Science Publishers Ltd.
Keyword Silybin
Cell biology
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
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Created: Sun, 09 May 2010, 00:06:40 EST