The influence of iron stores on cadmium body burden in a Thai population

Apinan, Roongnapa, Satarug, Soisunwan, Ruengweerayut, Ronnatrai, Mahavorasirikul, Wiratchanee and Na-Bangchang, Kesara (2010) The influence of iron stores on cadmium body burden in a Thai population. Environmental Geochemistry and Health, 32 3: 237-242. doi:10.1007/s10653-009-9280-3

Author Apinan, Roongnapa
Satarug, Soisunwan
Ruengweerayut, Ronnatrai
Mahavorasirikul, Wiratchanee
Na-Bangchang, Kesara
Title The influence of iron stores on cadmium body burden in a Thai population
Journal name Environmental Geochemistry and Health   Check publisher's open access policy
ISSN 0269-4042
Publication date 2010-06
Year available 2009
Sub-type Article (original research)
DOI 10.1007/s10653-009-9280-3
Volume 32
Issue 3
Start page 237
End page 242
Total pages 6
Place of publication Dordrecht, Netherlands
Publisher Springer Netherlands
Collection year 2011
Language eng
Abstract Cadmium is a toxin of increasing public health concern due to its presence in most human foodstuffs and in cigarette smoke. Exposure to cadmium leads to tissue bioaccumulation and, in particular, has nephrotoxic effects. The aim of the present study was to investigate the association between cadmium body burden and iron stores in a Thai population. A total of 182 healthy adult Thai subjects of both genders (89 males, 93 females) aged between 18 and 57 years and weighing 40-95 kg were included in this study. The total amounts of cadmium excreted in urine over 2 h (μg/g creatinine) were used as an index of long-term cadmium exposure. Quantitation of cadmium was performed using electrothermal (graphite furnace) atomic absorption spectrometry. The urinary cadmium excreted displayed a normal frequency distribution. The average urinary cadmium level did not exceed the WHO maximum tolerable internal dose for the non-exposed population (2 μg/g creatinine). Body iron stores reflected by serum ferritin levels did not show any correlation with cadmium burden in both males and females, although a relatively stronger influence of body iron store status on cadmium burden was shown in females. When the levels of serum ferritin were stratified into five levels (<20, 20-100, 101-200, 201-300, and >300 μg/l), a significant difference in total cadmium body burden was observed between females and males only in the group with a low level of serum ferritin of <20 μg/l. The cadmium body burden in females was about twice that in males in this group. © Springer Science+Business Media B.V. 2009.
Keyword Cadmium
Iron store
Thai population
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 6 October 2009

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
National Research Centre for Environmental Toxicology Publications
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Created: Sun, 09 May 2010, 00:04:33 EST