MTHFR C677T polymorphism and stroke: A north Indian study

Khullar, Madhu, Bajwa, Pratibha and Relan, Vandana (2003). MTHFR C677T polymorphism and stroke: A north Indian study. In: Circulation. Asia Pacific Scientific Forum on New Discoveries in Cardiovascular Disease and Stroke, Honolulu, Hawaii, (E177-E177). 8-10 June 2003.


Author Khullar, Madhu
Bajwa, Pratibha
Relan, Vandana
Title of paper MTHFR C677T polymorphism and stroke: A north Indian study
Conference name Asia Pacific Scientific Forum on New Discoveries in Cardiovascular Disease and Stroke
Conference location Honolulu, Hawaii
Conference dates 8-10 June 2003
Proceedings title Circulation   Check publisher's open access policy
Place of Publication Baltimore, MD, U.S.A.
Publisher Lippincott, Williams & Wilkins for the American Heart Association
Publication Year 2003
Sub-type Poster
ISSN 0009-7322
1524-4539
Volume 107
Issue 19
Start page E177
End page E177
Total pages 1
Language eng
Formatted Abstract/Summary
Introduction and Objectives: Hyperhomocysteinemia has been identified has a risk factor for cereberovascular ,peripheral vascular and coronary artery disease. Nonetheless a strong association between plasma homocysteine and risk of ischemic stroke has been reported recently. Elevated levels of plasma homocysteine can result from genetic and nutrient related disturbances in transsulfuration or remethylation pathways. Polymorphism in Methyl Tetra Hydro Folate Reductase(MTHFR) gene has been found to be associated with Hyperhomocysteinemia. In this study we have assed MTHFR C677T Polymorphism in ischemic stroke patients in North Indian population.

Methods: 80 stroke patients and 30 age and sex matched controls were enrolled for the study using Polymerse chain reaction and restriction analysis with Hinf 1 restriction enzyme .The relation between MTHFR C677T Polymorphism and ischemic stroke was evaluated

Results: The percentage and prevalence of different MTHFR C677T genotype in stroke patients and controls is given in the table: Allele frequency of the T allele was found to be nearly same in controls (13.3%) and stroke patients (13.13%). However further study using a large number of patients needs to establish a role between MTHFR C677T polymorphism and stroke.
Subjects 1103 Clinical Sciences
Keyword Ischemic stroke
Coronary artery disease
Plasma homocysteine
Hyperhomocysteinemia
MTHFR C677T polymorphism
North India
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Published in the issue section: Abstracts for the Asia Pacific Scientific Forum New Discoveries in Cardiovascular Disease and Stroke, Poster number: P187

 
Versions
Version Filter Type
Citation counts: Google Scholar Search Google Scholar
Created: Wed, 05 May 2010, 15:09:58 EST by Mary-Anne Marrington on behalf of Faculty Of Health Sciences