Cautionary tales in the interpretation of clinical studies involving older persons

Scott, IA and Guyatt, GH (2010) Cautionary tales in the interpretation of clinical studies involving older persons. Archives of Internal Medicine, 170 7: 387-395. doi:10.1001/archinternmed.2010.18

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Author Scott, IA
Guyatt, GH
Title Cautionary tales in the interpretation of clinical studies involving older persons
Journal name Archives of Internal Medicine   Check publisher's open access policy
ISSN 2168-6114
Publication date 2010-04-12
Sub-type Article (original research)
DOI 10.1001/archinternmed.2010.18
Open Access Status File (Publisher version)
Volume 170
Issue 7
Start page 387
End page 395
Total pages 9
Place of publication Chicago, IL, United States
Publisher American Medical Association
Collection year 2011
Language eng
Abstract The care of patients 65 years or older presents a challenge for evidence-based medicine. Such patients are underrepresented in clinical trials, are more vulnerable to treatment-induced harm, and often are unable to fully participate in treatment decisions. We outline several cautionary themes in the interpretation of clinical studies of therapeutic interventions involving older persons as they apply to processes of everyday clinical decision making. In particular, we focus on issues of study design and quality of evidence, choice of outcome measures, missing outcome data, assessment of potential harm, quantifying treatment effects in individual patients (and adjusting these for effect modifiers and reduced life expectancy), eliciting patient values and preferences, prioritizing therapeutic goals and selection of treatments, and assisting patients in adhering to agreed therapeutic regimens. ©2010 American Medical Association. All rights reserved.
Keyword St-segment elevation
Acute coronary syndromes
Randomized-controlled trial
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published under heading 'Special article'

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 1 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 25 Apr 2010, 00:06:50 EST