HFE C282Y homozygotes are at increased risk of breast and colorectal cancer

Osborne, NJ, Gurrin, LC, Allen, KJ, Constantine, CC, Delatycki, MB, McLaren, CE, Gertig, DM, Anderson, GJ, Southey, MC, Olynyk, JK, Powell, LW, Hopper, JL, Giles, GG and English, DR (2010) HFE C282Y homozygotes are at increased risk of breast and colorectal cancer. Hepatology, 51 4: 1311-1318. doi:10.1002/hep.23448

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Author Osborne, NJ
Gurrin, LC
Allen, KJ
Constantine, CC
Delatycki, MB
McLaren, CE
Gertig, DM
Anderson, GJ
Southey, MC
Olynyk, JK
Powell, LW
Hopper, JL
Giles, GG
English, DR
Title HFE C282Y homozygotes are at increased risk of breast and colorectal cancer
Journal name Hepatology   Check publisher's open access policy
ISSN 0270-9139
Publication date 2010-04
Year available 2009
Sub-type Article (original research)
DOI 10.1002/hep.23448
Volume 51
Issue 4
Start page 1311
End page 1318
Total pages 8
Place of publication Hokoben, NJ, USA
Publisher John Wiley & Sons
Collection year 2011
Language eng
Formatted abstract
The evidence that mutations in the HFE gene for hemochromatosis are associated with increased cancer risk is inconsistent. The Melbourne Collaborative Cohort Study is a prospective cohort study that commenced recruitment in 1990. Participants born in Australia, New Zealand, the United Kingdom, or Ireland (n = 28,509) were genotyped for the HFE C282Y (substitution of tyrosine for cysteine at amino acid 282) variant. Incident cancers were ascertained from Australian cancer registries during an average of 14 years follow-up. Hazard ratios (HRs), confidence intervals (CIs), and P values were obtained from separate Cox regression analyses for colorectal, breast, and prostate cancers, all other solid cancers, and all cancers. Compared to those with no C282Y variant, C282Y homozygotes were at increased risk of colorectal cancer (HR = 2.28; 95% CI = 1.22, 4.25; P = 0.01) and female C282Y homozygotes were at increased risk of developing breast cancer (HR = 2.39; 95% CI = 1.24, 4.61; P = 0.01), but male C282Y homozygotes were not at increased risk for prostate cancer (HR = 0·96; 95% CI = 0·43, 2·15; P = 0.92). C282Y/H63D compound heterozygotes were not at increased risk for colorectal cancer (HR = 1.27; 95% CI = 0.80, 2.01), breast cancer (HR = 1.16; 95% CI = 0.74, 1.84), or prostate cancer (HR = 1.08; 95% CI = 0.68, 1.70). Conclusion: HFE C282Y homozygotes have twice the risk of colorectal and breast cancer compared with those individuals without the C282Y variant. (HEPATOLOGY 2010.)
Copyright © 2009 American Association for the Study of Liver Diseases

Keyword Breast neoplasms
Colorectal neoplasms
Histocompatibility antigens class I
Membrane proteins
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Article first published online: 30 Nov 2009

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
Official 2011 Collection
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 59 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 67 times in Scopus Article | Citations
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Created: Sun, 25 Apr 2010, 00:04:13 EST