Hepcidin expression is down-regulated in alcohol-fed rats: A possible pathogenic factor in alcohol related hepatic siderosis.

Bridle, Kim, Cheung, Ting Kin, Crawford, Darrell, Fletcher, Linda and Murphy, Therese (2003). Hepcidin expression is down-regulated in alcohol-fed rats: A possible pathogenic factor in alcohol related hepatic siderosis.. In: Hepatology. Proceedings of: 55th Annual Meeting of the American Association for the Study of Liver Diseases. The Liver Meeting 2003: 54th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, MA, U.S.A., (661A-661A). 25-28 October 2003. doi:10.1002/hep.1840380508


Author Bridle, Kim
Cheung, Ting Kin
Crawford, Darrell
Fletcher, Linda
Murphy, Therese
Title of paper Hepcidin expression is down-regulated in alcohol-fed rats: A possible pathogenic factor in alcohol related hepatic siderosis.
Conference name The Liver Meeting 2003: 54th Annual Meeting of the American Association for the Study of Liver Diseases
Conference location Boston, MA, U.S.A.
Conference dates 25-28 October 2003
Proceedings title Hepatology. Proceedings of: 55th Annual Meeting of the American Association for the Study of Liver Diseases
Place of Publication 0270-9139 (print); 1527-3350 (electronic)
Publisher John Wiley & Sons
Publication Year 2003
Sub-type Poster
DOI 10.1002/hep.1840380508
Volume 38
Issue 4 Suppl. 1
Start page 661A
End page 661A
Total pages 1
Language eng
Formatted Abstract/Summary
Introduction
Both alcohol and excess iron in the liver can induce tissue damage and lead to fibrosis and ultimately cirrhosis. Hepatic siderosis is often seen in patients with alcoholic liver disease. The pathogenic mechanisms underlying this phenomenon have not been well characterized. Hepcidin, a recently discovered liver-derived circulating peptide, has been implicated in the homeostasis of iron metabolism and in the regulation of iron absorption. Hepcidin is believed to be a negative regulator of intestinal iron absorption. Divalent metal transporter 1 (DMT1) and iron-regulated protein (IREG1) are the major iron transporters in duodenal enterocytes, with DMT1 responsible for apical uptake and IREG1 for basolateral export of iron. The effect of alcohol on the expression of hepcidin, DMT1 and IREG1 is not known.

Conclusion
Hepcidin expression is significantly decreased in the alcohol-fed rats. Altered hepcidin expression may be an important contributing factor to hepatic siderosis often seen in human alcoholic liver disease.
Subjects 1103 Clinical Sciences
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Presented during "Metabolic Liver Diseases" as Poster no. 1050. Publication mistitled as "55th Annual Meeting".

 
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Created: Fri, 23 Apr 2010, 15:21:34 EST by Jon Swabey on behalf of Faculty Of Health Sciences