Immunopathogenesis of human schistosomiasis

Burke, M. L., Jones, M. K., Gobert, G. N., Li, Y. S., Ellis, M. K. and McManus, D. P. (2009) Immunopathogenesis of human schistosomiasis. Parasite Immunology, 31 4: 163-176. doi:10.1111/j.1365-3024.2009.01098.x

Author Burke, M. L.
Jones, M. K.
Gobert, G. N.
Li, Y. S.
Ellis, M. K.
McManus, D. P.
Title Immunopathogenesis of human schistosomiasis
Journal name Parasite Immunology   Check publisher's open access policy
ISSN 0141-9838
Publication date 2009-01-16
Year available 2009
Sub-type Article (original research)
DOI 10.1111/j.1365-3024.2009.01098.x
Volume 31
Issue 4
Start page 163
End page 176
Total pages 14
Editor Riley, Eleanor M.
Grencis, Richard K.
Place of publication Oxford
Publisher Blackwell Scientific Publications
Collection year 2010
Language eng
Subject 110803 Medical Parasitology
920108 Immune System and Allergy
Abstract Schistosomiasis continues to be a significant cause of parasitic morbidity and mortality worldwide. This review considers the basic features of the pathology and clinical outcomes of hepatointestinal and genitourinary schistosomiasis, presents an overview of the numerous studies on animal models that have clarified many of the immunopathological features, and provides insight into our current understanding of the immunopathogenesis and genetic control of human schistosomiasis. In murine schistosomiasis, pathology is induced by a CD4+ Th2 driven granulomatous response directed against schistosome eggs lodged in the host liver. The Th2 cytokines IL-4 and IL-13 drive this response, whereas IL-10, IL13Rα2, IFN-γ and a subset of regulatory T-cells act to limit schistosome induced pathology. A variety of cell types including hepatic stellate cells, alternatively activated macrophages and regulatory T-cells have also been implicated in the pathogenesis of schistosomiasis. Current knowledge suggests the immunopathogenic mechanisms underlying human schistosomiasis are likely to be similar. The review also considers the future development of anti-pathology schistosome vaccines. As fibrosis is an important feature of many other diseases such as Crohn's disease and sarcoidosis, a comprehensive understanding of the cellular and molecular mechanisms involved in schistosomiasis may also ultimately contribute to the development an effective disease intervention strategy for other granulofibrotic diseases.
Keyword chemokine
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Public Health Publications
School of Veterinary Science Publications
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Citation counts: TR Web of Science Citation Count  Cited 126 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 150 times in Scopus Article | Citations
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Created: Thu, 22 Apr 2010, 14:55:53 EST by Rebecca Wotton on behalf of School of Veterinary Science