Genomewide screens in ankylosing spondylitis

Brown, Matthew A. (2009). Genomewide screens in ankylosing spondylitis. In Carlos Lopez-Larrea and Roberto Diaz-Pena (Ed.), Molecular mechanisms of spondyloarthropathies (pp. 148-158) New York, United States: Springer Science + Business Media. doi:10.1007/978-1-4419-0298-6


Author Brown, Matthew A.
Title of chapter Genomewide screens in ankylosing spondylitis
Title of book Molecular mechanisms of spondyloarthropathies
Place of Publication New York, United States
Publisher Springer Science + Business Media
Publication Year 2009
Sub-type Research book chapter (original research)
DOI 10.1007/978-1-4419-0298-6
Series Advances in Experimental Medicine and Biology
ISBN 9781441902979
ISSN 0065-2598
Editor Carlos Lopez-Larrea
Roberto Diaz-Pena
Volume number 649
Chapter number 11
Start page 148
End page 158
Total pages 11
Total chapters 23
Collection year 2010
Language eng
Subjects B1
970111 Expanding Knowledge in the Medical and Health Sciences
970106 Expanding Knowledge in the Biological Sciences
920116 Skeletal System and Disorders (incl. Arthritis)
060405 Gene Expression (incl. Microarray and other genome-wide approaches)
110322 Rheumatology and Arthritis
Abstract/Summary Efforts to identify genes other than HLA-B27 in AS have been driven by the strength of the evidence from genetic epidemiology studies indicating that HLA-B27, although a major gene in AS, is clearly not the only significant gene operating. This is the case for both genetic determinants of disease-susceptibility and phenotypic characteristics such as disease severity and associated disease features. In this chapter the genetic epidemiology of AS and the gene-mapping studies performed to date will be reviewed and the future direction of research in this field discussed.
Keyword Inflammatory bowel disease
Acute anterior uveitis
Crohns disease
Polymorphisms
Q-Index Code B1
Q-Index Status Confirmed Code
Institutional Status UQ

 
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Created: Thu, 22 Apr 2010, 12:33:39 EST by Kylie Hengst on behalf of UQ Diamantina Institute