Evolutionary genomics of the Fox genes: Origin of gene families and the ancestry of gene clusters

Shimeld, Sebastian M., Degnan, Bernard M. and Luke, Graham N. (2010) Evolutionary genomics of the Fox genes: Origin of gene families and the ancestry of gene clusters. Genomics, 95 5: 256-260. doi:10.1016/j.ygeno.2009.08.002


Author Shimeld, Sebastian M.
Degnan, Bernard M.
Luke, Graham N.
Title Evolutionary genomics of the Fox genes: Origin of gene families and the ancestry of gene clusters
Journal name Genomics   Check publisher's open access policy
ISSN 0888-7543
Publication date 2010-05
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.ygeno.2009.08.002
Volume 95
Issue 5
Start page 256
End page 260
Total pages 5
Editor J. Quackenbush
Place of publication United States
Publisher Academic Press
Collection year 2010
Language eng
Subject 970106 Expanding Knowledge in the Biological Sciences
060409 Molecular Evolution
C1
Abstract Over the past decade genomic approaches have begun to revolutionise the study of animal diversity. In particular, genome sequencing programmes have spread beyond the traditional model species to encompass an increasing diversity of animals from many different phyla, as well as unicellular eukaryotes that are closely related to the animals. Whole genome sequences allow researchers to establish, with reasonable confidence, the full complement of any particular family of genes in a genome. Comparison of gene complements from appropriate genomes can reveal the evolutionary history of gene families, indicating when both gene diversification and gene loss have occurred. More than that, however, assembled genomes allow the genomic environment in which individual genes are found to be analysed and compared between species. This can reveal how gene diversification occurred. Here, we focus on the Fox genes, drawing from multiple animal genomes to develop an evolutionary framework explaining the timing and mechanism of origin of the diversity of animal Fox genes. Ancient linkages between genes are a prominent feature of the Fox genes, depicting a history of gene clusters, some of which may be relevant to understanding Fox gene function.
Keyword Fox gene
Gene cluster
Gene duplication
Gene loss
Q-Index Code C1
Q-Index Status Confirmed Code

 
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Created: Wed, 21 Apr 2010, 14:54:45 EST by Hayley Ware on behalf of School of Biological Sciences