Is complement factor H a susceptibility factor for IgA nephropathy?

Edey, M.J., Strain, L, Ward, R, Ahmed, S, Thomas, T and Goodship, T.H. (2009) Is complement factor H a susceptibility factor for IgA nephropathy?. Molecular Immunology, 46 7: 1405-1408. doi:10.1016/j.molimm.2008.12.002


Author Edey, M.J.
Strain, L
Ward, R
Ahmed, S
Thomas, T
Goodship, T.H.
Title Is complement factor H a susceptibility factor for IgA nephropathy?
Journal name Molecular Immunology   Check publisher's open access policy
ISSN 0161-5890
Publication date 2009-04
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.molimm.2008.12.002
Volume 46
Issue 7
Start page 1405
End page 1408
Total pages 4
Editor M. R. Daha
Place of publication United Kingdom
Publisher Pergamon
Collection year 2010
Language eng
Subject C1
92 Health
11 Medical and Health Sciences
Abstract There is substantial evidence to suggest that complement activation plays a pivotal role in the pathogenesis of IgA nephropathy. Mesangial C3 deposition is seen in not, vert, similar90% of patients and polymeric IgA has been shown to activate the alternative and lectin pathways. In addition there have been reports of deficiency and mutations in the serum complement regulator factor H (CFH) in association with IgA nephropathy. In this study we have examined the hypothesis that CFH is a susceptibility factor for IgA nephropathy. In 46 IgA nephropathy patients we undertook genotyping of three CFH SNPS (rs3753394, rs3753396 and rs1065489). There was no significant difference in the allele frequency of these 3 SNPs between the patients and normal controls. In the same group of patients we undertook mutation screening of CFH exons 18–23 using direct sequencing and found no abnormalities. All the patients had a normal serum factor H concentration. In this small cohort of IgA nephropathy patients we have not found evidence to support the hypothesis that factor H is a major susceptibility factor for the disease.
Keyword Complement
IgA nephropathy
Genetics
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 21 Apr 2010, 14:51:09 EST by Jon Stekhoven on behalf of School of Medicine