Meta-analysis of immune epitope data for all Plasmodia: overview and applications for malarial immunobiology and vaccine-related issues

Vaughan, K., Blythe, M., Greenbaum, J., Zhang, Q., Peters, B., Doolan, D.L. and Sette, A. (2009) Meta-analysis of immune epitope data for all Plasmodia: overview and applications for malarial immunobiology and vaccine-related issues. Parasite Immunology, 31 2: 78-97. doi:10.1111/j.1365-3024.2008.01077.x


Author Vaughan, K.
Blythe, M.
Greenbaum, J.
Zhang, Q.
Peters, B.
Doolan, D.L.
Sette, A.
Title Meta-analysis of immune epitope data for all Plasmodia: overview and applications for malarial immunobiology and vaccine-related issues
Journal name Parasite Immunology   Check publisher's open access policy
ISSN 0141-9838
1365-3024
Publication date 2009-02
Year available 2008
Sub-type Article (original research)
DOI 10.1111/j.1365-3024.2008.01077.x
Volume 31
Issue 2
Start page 78
End page 97
Total pages 20
Editor Eleanor Riley
Richard Grencis
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Language eng
Subject 92 Health
11 Medical and Health Sciences
Abstract We present a comprehensive meta-analysis of more than 500 references, describing nearly 5000 unique B cell and T cell epitopes derived from the Plasmodium genus, and detailing thousands of immunological assays. This is the first inventory of epitope data related to malaria-specific immunology, plasmodial pathogenesis, and vaccine performance. The survey included host and pathogen species distribution of epitopes, the number of antibody vs. CD4(+) and CD8(+) T cell epitopes, the genomic distribution of recognized epitopes, variance among epitopes from different parasite strains, and the characterization of protective epitopes and of epitopes associated with parasite evasion of the host immune response. The results identify knowledge gaps and areas for further investigation. This information has relevance to issues, such as the identification of epitopes and antigens associated with protective immunity, the design and development of candidate malaria vaccines, and characterization of immune response to strain polymorphisms.
Keyword Malaria
Epitope
Plasmodium
Vaccine
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article first published online: 30 October 2008

Document type: Journal Article
Sub-type: Article (original research)
Collections: ERA 2012 Admin Only
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Created: Wed, 21 Apr 2010, 12:52:32 EST by Jon Stekhoven on behalf of School of Medicine