Nontuberculous mycobacterial infection in children: A prospective national study

Blyth, Christopher C., Best, Emma J., Jones, Cheryl A., Nourse, Clare, Goldwater, Paul N., Daley, Andrew J., Burgner, David, Henry, Guy and Palasanthiran, Pamela (2009) Nontuberculous mycobacterial infection in children: A prospective national study. The Pediatric Infectious Disease Journal, 28 9: 801-805. doi:10.1097/INF.0b013e31819f7b3f


Author Blyth, Christopher C.
Best, Emma J.
Jones, Cheryl A.
Nourse, Clare
Goldwater, Paul N.
Daley, Andrew J.
Burgner, David
Henry, Guy
Palasanthiran, Pamela
Title Nontuberculous mycobacterial infection in children: A prospective national study
Journal name The Pediatric Infectious Disease Journal   Check publisher's open access policy
ISSN 0891-3668
Publication date 2009-09
Sub-type Article (original research)
DOI 10.1097/INF.0b013e31819f7b3f
Volume 28
Issue 9
Start page 801
End page 805
Total pages 5
Editor Jansen, K.
Place of publication United States
Publisher Lippincott Williams and Wilkins
Collection year 2010
Language eng
Abstract Background: The epidemiology and management of nontuberculous mycobacterial (NTM) infection in Australian children is unknown. Methods: From July 2004 to June 2007, clinicians identified children with NTM infection as part of a nationwide active surveillance network. Following notification, detailed data were collected. Results: From 192 reports, data were received on 153 cases (response rate: 79.7%). Of these, 102 met inclusion criteria. The median age was 2.9 years. Predisposing conditions were infrequent and included chronic respiratory disease (n = 12) and immunosuppression (n = 6). Lymphadenitis was the most frequent presentation (n = 68) with pulmonary and disseminated disease infrequent (n = 14 and 3, respectively). NTM was isolated in 68 cases with Mycobacterium avium-intracellulare complex most frequently isolated (33/68; 48.5%). Surgery was performed in 78 cases and 42 children were treated with antimycobacterial therapy. Twenty-five subjects received surgery and antimycobacterial therapy. Follow-up data were available for 77 children with recurrence observed in 18 cases. Complete excision was associated with a higher rate of treatment success when compared with all other therapies (OR: 9.48 [95% CI: 2.00-44.97], P = 0.001). Mycobacterium lentiflavum infection accounted for 4.4% of culture confirmed cases and had a lower rate of treatment success than other species (0% vs. 78.2%; P = 0.016). Conclusions: The incidence of NTM infection in Australian children is 0.84 of 100,000 (95% CI: 0.68-1.02). Infection occurs most often in young children without predisposing conditions. Despite therapy, there was recurrence in 23.4% of cases.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Medicine Publications
 
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Created: Tue, 20 Apr 2010, 16:55:16 EST by Maree Knight on behalf of Medicine - Princess Alexandra Hospital