Development of therapeutic HPV vaccines

Trimble, C. L. and Frazer, Ian H. (2010) Development of therapeutic HPV vaccines. Lancet Oncology, 10 10: 975-980. doi:10.1016/S1470-2045(09)70227-X


Author Trimble, C. L.
Frazer, Ian H.
Title Development of therapeutic HPV vaccines
Journal name Lancet Oncology   Check publisher's open access policy
ISSN 1470-2045
Publication date 2010-10
Year available 2009
Sub-type Article (original research)
DOI 10.1016/S1470-2045(09)70227-X
Volume 10
Issue 10
Start page 975
End page 980
Total pages 6
Editor Collingridge, D.
Place of publication United Kingdom
Publisher The Lancet Publishing Group
Collection year 2010
Language eng
Subject C1
970111 Expanding Knowledge in the Medical and Health Sciences
920102 Cancer and Related Disorders
920108 Immune System and Allergy
111716 Preventive Medicine
110309 Infectious Diseases
Abstract At least 15% of human malignant diseases are attributable to the consequences of persistent viral or bacterial infection. Chronic infection with oncogenic human papillomavirus (HPV) types is a necessary, but insufficient, cause in the development of more cancers than any other virus. Currently available prophylactic vaccines have no therapeutic effect for established infection or for disease. Early disease is characterised. by tissue sequestration. However, because a proportion of intraepithelial HPV-associated disease undergoes immune-mediated regression, the development of immunotherapeutic strategies is an opportunity to determine proof-of-principle for therapeutic vaccines. In this Review, we discuss recent progress in this field and priorities for future clinical investigations.
Keyword CERVICAL INTRAEPITHELIAL NEOPLASIA
HUMAN-PAPILLOMAVIRUS TYPE-16
MEDIATED IMMUNE-RESPONSES
CYTOTOXIC T-LYMPHOCYTES
VIRUS-LIKE PARTICLES
PHASE-I TRIAL
NATURAL-HISTORY
ANTIBODY-RESPONSES
CELL RESPONSES
PHYSICAL STATE
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
UQ Diamantina Institute Publications
 
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Created: Tue, 20 Apr 2010, 14:49:12 EST by Kylie Hengst on behalf of UQ Diamantina Institute