Accrediting radiation technique in a multicentre trial of chemoradiation for pancreatic cancer

Spry, N., Bydder, S., Harvey, J., Borg, M., Ngan, S., Millar, J., Graham, P., Zissiadis, Y., Kneebone, A. and Ebert, M. (2009) Accrediting radiation technique in a multicentre trial of chemoradiation for pancreatic cancer. Journal of medical imaging and radiation oncology, 52 6: 598-604. doi:10.1111/j.1440-1673.2008.02026.x

Author Spry, N.
Bydder, S.
Harvey, J.
Borg, M.
Ngan, S.
Millar, J.
Graham, P.
Zissiadis, Y.
Kneebone, A.
Ebert, M.
Title Accrediting radiation technique in a multicentre trial of chemoradiation for pancreatic cancer
Journal name Journal of medical imaging and radiation oncology   Check publisher's open access policy
ISSN 1754-9485
Publication date 2009
Year available 2009
Sub-type Article (original research)
DOI 10.1111/j.1440-1673.2008.02026.x
Volume 52
Issue 6
Start page 598
End page 604
Total pages 7
Editor Ball, D.
Place of publication Australia
Publisher Wiley-Blackwell Publishing Asia
Collection year 2010
Language eng
Subject C1
970111 Expanding Knowledge in the Medical and Health Sciences
111208 Radiation Therapy
Abstract Before a multicentre trial of 3-D conformal radiotherapy to treat cancer of the pancreas, participating clinicians were asked to complete an accreditation exercise. This involved planning two test cases according to the study protocol, then returning hard copies of the plans and dosimetric data for review. Any radiation technique that achieved the specified constraints was allowed. Eighteen treatment plans were assessed. Seven plans were prescribed incorrect doses and two of the planning target volumes did not comply with protocol guidelines. All plans met predefined normal tissue dose constraints. The identified errors were attributable to unforeseen ambiguities in protocol documentation. They were addressed by feedback and corresponding amendments to protocol documentation. Summary radiobiological measures including total weighted normal tissue equivalent uniform dose varied significantly between centres. This accreditation exercise successfully identified significant potential sources of protocol violations, which were then easily corrected. We believe that this process should be applied to all clinical trials involving radiotherapy. Due to the limitations of data analysis with hard-copy information only, it is recommended that complete planning datasets from treatment-planning systems be collected through a digital submission process.
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 3 times in Thomson Reuters Web of Science Article | Citations
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Created: Tue, 20 Apr 2010, 12:34:58 EST by Maree Knight on behalf of Medicine - Princess Alexandra Hospital