Efficacy and tolerability of concurrent weekly low dose cisplatin during radiation treatment of localised muscle invasive bladder transitional cell carcinoma: A report of two sequential phase II studies from TROG

Gogna, N. K., Matthews, J. H. L., Turner, S. L., Mameghan, H., Duchesne, G. M., Spry, N., Berry, M. P., Keller, J. and Tripcony, L. (2006). Efficacy and tolerability of concurrent weekly low dose cisplatin during radiation treatment of localised muscle invasive bladder transitional cell carcinoma: A report of two sequential phase II studies from TROG. In: Australasian Radiology. Proceedings of: Faculty of Radiation Oncology 2006 Singapore Meeting. RANZCR Faculty of Radiation Oncology (FRO) 2006 Annual Scientific Meeting, Singapore, Republic of Singapore, (A68-A68). 15-17 November 2006. doi:10.1111/j.1440-1673.2006.01673.x


Author Gogna, N. K.
Matthews, J. H. L.
Turner, S. L.
Mameghan, H.
Duchesne, G. M.
Spry, N.
Berry, M. P.
Keller, J.
Tripcony, L.
Title of paper Efficacy and tolerability of concurrent weekly low dose cisplatin during radiation treatment of localised muscle invasive bladder transitional cell carcinoma: A report of two sequential phase II studies from TROG
Conference name RANZCR Faculty of Radiation Oncology (FRO) 2006 Annual Scientific Meeting
Conference location Singapore, Republic of Singapore
Conference dates 15-17 November 2006
Proceedings title Australasian Radiology. Proceedings of: Faculty of Radiation Oncology 2006 Singapore Meeting   Check publisher's open access policy
Place of Publication Carlton South, Vic., Australia
Publisher Wiley-Blackwell Publishing Asia
Publication Year 2006
DOI 10.1111/j.1440-1673.2006.01673.x
ISSN 0004-8461
1440-1673
Volume 50
Issue Supp. 2
Start page A68
End page A68
Total pages 1
Language eng
Formatted Abstract/Summary
Background
Several Phase II studies of cisplatin based concurrent chemoradiation have suggested that this approach is better than radiation alone in the management of muscle invasive TCC of the Urinary Bladder. Thus far, there is no widely accepted standard protocol for the delivery of the combined treatment. The primary objective during concurrent chemoradiation is to maximise radiosensitisation. One way to achieve this would be to give the drug as frequently as practical with the radiation. This formed the basis of our two sequential studies of low dose weekly cisplatin and radiation treatment.

Conclusions
Concurrent chemoradiation using weekly cisplatin in the management of invasive bladder TCC is feasible and is being investigated further in a randomised study.
Journal compilation © 2006 Royal Australian and New Zealand College of Radiologists
Subjects 1112 Oncology and Carcinogenesis
1007 Nanotechnology
1103 Clinical Sciences
Q-Index Code EX
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Original Title: "Chemo-radiation in the definitive treatment of muscle invasive bladder cancer". Published as Oral Session "O39". Conference Convenor: Dr Rahul Mukherjee.

 
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Created: Mon, 19 Apr 2010, 14:30:50 EST by Jon Swabey on behalf of Faculty Of Health Sciences