Measurement of arterial distensibility and compliance to assess prognosis

Haluska, Brian A., Jeffries, Leanne, Carlier, Stephane and Marwick, Thomas H. (2010) Measurement of arterial distensibility and compliance to assess prognosis. Atherosclerosis, 209 2: 474-480. doi:10.1016/j.atherosclerosis.2009.10.018


Author Haluska, Brian A.
Jeffries, Leanne
Carlier, Stephane
Marwick, Thomas H.
Title Measurement of arterial distensibility and compliance to assess prognosis
Journal name Atherosclerosis   Check publisher's open access policy
ISSN 0021-9150
Publication date 2010-04
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.atherosclerosis.2009.10.018
Volume 209
Issue 2
Start page 474
End page 480
Total pages 7
Place of publication Shannon, Co. Clare Ireland
Publisher Elsevier Ireland
Collection year 2011
Language eng
Formatted abstract
Background and aim
Total arterial compliance (TAC) reflects arterial function in the entire systemic circulation while distensibility coefficient (DC) is an estimate of local arterial compliance obtained from large elastic arteries. There are few studies relating TAC or DC to outcome. We sought whether DC or TAC predicted outcome in a primary prevention cohort with a spectrum of cardiovascular risk.

Methods
Clinical data including blood pressure (BP) and diabetes mellitus (DM) were obtained and Framingham 10-year risk was calculated in 719 primary prevention patients (373 men; age 55 ± 11 years). TAC was calculated from applanation tonometry using the pulse-pressure method, 2D-echocardiography and Doppler, and DC was derived from 2D measurements of the common carotid artery and pulse pressure (PP). Cox regression analysis was performed to determine correlates of outcome.

Results
There were 42 deaths (5.8%) and 114 cardiovascular admissions (15.8%) over 57 months. The independent correlates of mortality were Framingham 10-year risk (HR = 1.69; p < 0.0001) and DC (HR = 0.54; p = 0.02) (model chi-square 24.52; p < 0.0001) but not TAC. The independent predictors of the composite outcome of either death or admission for cardiovascular causes were Framingham 10-year risk (HR = 1.28; p = 0.001) and TAC (HR = 0.75; p = 0.006) (model chi-square 21.43; p < 0.0001) but not DC.

Conclusions
Measurement of arterial function is independently correlated with outcome in patients with varying degrees of cardiovascular risk, and different aspects identify fatal and non-fatal events. In addition, measurement of TAC and DC adds incremental benefit to Framingham risk scores alone in patients with intermediate cardiovascular risk.
Copyright © 2009 Elsevier Ireland Ltd All rights reserved.
Keyword Total arterial compliance
Arterial distensibility
Framingham risk
Outcome
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 22 October 2009.

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Medicine Publications
 
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Created: Sun, 18 Apr 2010, 00:08:03 EST