Six new loci associated with body mass index highlight a neuronal influence on body weight regulation

Willer, Cristen J., Speliotes, Elizabeth K., Loos, Ruth J. F., Li, Shengxu, Lindgren, Cecilia M., Heid, Iris M., Berndt, Sonja I., Elliot, Amanda L., Jackson, Anne U., Lamina, Claudia, Lettre, Guillaume, Lim, Noha, Lyon, Helen N., McCarroll, Steven N., Papadakis, Konstantinos, Qi, Lu, Randall, Joshua C., Roccasecca, Rosa Maria, Sanna, Serena, Scheet, Paul, Weedon, Michael N., Wheeler, Eleanor, Zhao, Jing Hua, Jacobs, Leonie C., Prokopenko,, Soranzo, Nicole, Tanaka, Toshiko, Timpson, Nicholas J., Almgran, Peter, Bennett, Amanda, Bergman, Richard N., Bingham, Sheila A., Bonnycastle, Lori L., Brown, Morris, Bertt, Noel P., Chines, Peter, Coin, Lachlan, Collins, Frances S., Connell, John M., Cooper, Cyrus, Smith, George Davey, Dennison, Elaine M., Deodhar, Parimal, Elliott, Paul, Erdos, Michael R., Estrada, Karol, Evans, David M., Gianniny, Lauren, Gieger, Christian, Gillson, Christopher J., Guiducci, Candace, Hackett, Rachel, Hadley, David, Hall, Alistair S., Havulinna, Aki S., Hebebrand, Johannes, Hofman, Albert, Isomaa, Bo, Jacobs, Kevin B., Johnson, Toby, Jousilahti, Pekka, Jovanovic, Zorica, Kaw, Kay-Tee, Kraft, Peter, Kuokkanen, Mikko, Kuusisto, Johanna, Laitinen, Jaana, Lakatta, Edward G., Luan, Jian'an, Luben, Robert N., Mangino, Massimo, McArdle, Wendy L., Meitinger, Thomas, Mulas, Antonella, Munroe, Patricia B., Narisu, Narisu, Ness, Andrew R., Northstone, Kate, O'Rahilly, Stephenen, Purmann, Carolin, Rees, Matthew G., Ridderstråle, Martin, Ring, Susan M., Rivadeneira, Fernando, Ruokonen, Aimo, Sandhu, Manjinder, Saramies, Jouko, Scott, Laura J., Scuteri, Angelo, Silander, Kaisa, Sims, Matthew A., Song, Kijoung, Stephens, Jonathan, Stevens, Suzanne, Stringham, Heather M., Tung, Y. C. Loraine, Valle, Timo T., Van Duijn, Cornelia M., Vimaleswaran, Karani, Vollenweider, Peter, Waeber, Gerard, Wallace, Chris, Watanabe, Richard, Waterworth, Dawn M., Watkins, Nicholas, Wittemann, Jacqueline, Zeggini, Eleftheria, Zhai, Guangju, Zillikens, M. Carola, Altshuler, David, Caulfield, Mark J., Chanock, Stephen J., Farooqi, I. Sadaf, Ferrucci, Luigi, Guralnik, Jack M., Hattersley, Andrew T, Hu, Frank B., Jarvelin, Marjo-Riitta, Laakso, Markku, Mooser, Vincent, Ong, Ken K., Ouwehand, Willem H., Salomaa, Veikko, Samani, Nilesh, Spector, Timothy D., Tuomi, Tiinamaija, Tuomilehto, Jaakko, Uda, Manuela, Uitterlinden, Andre G., Wareham, Nicholas J., Deloukas, Panagiotis, Frayling, Timothy M., Groop, Leif C., Hayes, Richard B., Hunter, David J., Mohlke, Karen L., Peltonen, Leena, Schlessinger, David, Strachan, David P., Wichmann, H. Erich, McCarthy, Mark I., Boehnke, Michael, Barroso, Ines, Abecasis, Goncalo, Hirschhorn, Joel N., Bradbury, Linda M., Brown, Matthew A. and GIANT consortium (2009) Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nature Genetics, 41 1: 25-34. doi:10.1038/ng.287


Author Willer, Cristen J.
Speliotes, Elizabeth K.
Loos, Ruth J. F.
Li, Shengxu
Lindgren, Cecilia M.
Heid, Iris M.
Berndt, Sonja I.
Elliot, Amanda L.
Jackson, Anne U.
Lamina, Claudia
Lettre, Guillaume
Lim, Noha
Lyon, Helen N.
McCarroll, Steven N.
Papadakis, Konstantinos
Qi, Lu
Randall, Joshua C.
Roccasecca, Rosa Maria
Sanna, Serena
Scheet, Paul
Weedon, Michael N.
Wheeler, Eleanor
Zhao, Jing Hua
Jacobs, Leonie C.
Prokopenko,
Soranzo, Nicole
Tanaka, Toshiko
Timpson, Nicholas J.
Almgran, Peter
Bennett, Amanda
Bergman, Richard N.
Bingham, Sheila A.
Bonnycastle, Lori L.
Brown, Morris
Bertt, Noel P.
Chines, Peter
Coin, Lachlan
Collins, Frances S.
Connell, John M.
Cooper, Cyrus
Smith, George Davey
Dennison, Elaine M.
Deodhar, Parimal
Elliott, Paul
Erdos, Michael R.
Estrada, Karol
Evans, David M.
Gianniny, Lauren
Gieger, Christian
Gillson, Christopher J.
Guiducci, Candace
Hackett, Rachel
Hadley, David
Hall, Alistair S.
Havulinna, Aki S.
Hebebrand, Johannes
Hofman, Albert
Isomaa, Bo
Jacobs, Kevin B.
Johnson, Toby
Jousilahti, Pekka
Jovanovic, Zorica
Kaw, Kay-Tee
Kraft, Peter
Kuokkanen, Mikko
Kuusisto, Johanna
Laitinen, Jaana
Lakatta, Edward G.
Luan, Jian'an
Luben, Robert N.
Mangino, Massimo
McArdle, Wendy L.
Meitinger, Thomas
Mulas, Antonella
Munroe, Patricia B.
Narisu, Narisu
Ness, Andrew R.
Northstone, Kate
O'Rahilly, Stephenen
Purmann, Carolin
Rees, Matthew G.
Ridderstråle, Martin
Ring, Susan M.
Rivadeneira, Fernando
Ruokonen, Aimo
Sandhu, Manjinder
Saramies, Jouko
Scott, Laura J.
Scuteri, Angelo
Silander, Kaisa
Sims, Matthew A.
Song, Kijoung
Stephens, Jonathan
Stevens, Suzanne
Stringham, Heather M.
Tung, Y. C. Loraine
Valle, Timo T.
Van Duijn, Cornelia M.
Vimaleswaran, Karani
Vollenweider, Peter
Waeber, Gerard
Wallace, Chris
Watanabe, Richard
Waterworth, Dawn M.
Watkins, Nicholas
Wittemann, Jacqueline
Zeggini, Eleftheria
Zhai, Guangju
Zillikens, M. Carola
Altshuler, David
Caulfield, Mark J.
Chanock, Stephen J.
Farooqi, I. Sadaf
Ferrucci, Luigi
Guralnik, Jack M.
Hattersley, Andrew T
Hu, Frank B.
Jarvelin, Marjo-Riitta
Laakso, Markku
Mooser, Vincent
Ong, Ken K.
Ouwehand, Willem H.
Salomaa, Veikko
Samani, Nilesh
Spector, Timothy D.
Tuomi, Tiinamaija
Tuomilehto, Jaakko
Uda, Manuela
Uitterlinden, Andre G.
Wareham, Nicholas J.
Deloukas, Panagiotis
Frayling, Timothy M.
Groop, Leif C.
Hayes, Richard B.
Hunter, David J.
Mohlke, Karen L.
Peltonen, Leena
Schlessinger, David
Strachan, David P.
Wichmann, H. Erich
McCarthy, Mark I.
Boehnke, Michael
Barroso, Ines
Abecasis, Goncalo
Hirschhorn, Joel N.
Bradbury, Linda M.
Brown, Matthew A.
GIANT consortium
Title Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
Publication date 2009-01
Year available 2008
Sub-type Article (original research)
DOI 10.1038/ng.287
Volume 41
Issue 1
Start page 25
End page 34
Total pages 10
Place of publication United States
Publisher Nature Publishing Group
Language eng
Subject C1
970106 Expanding Knowledge in the Biological Sciences
970111 Expanding Knowledge in the Medical and Health Sciences
920103 Cardiovascular System and Diseases
920106 Endocrine Organs and Diseases (excl. Diabetes)
060405 Gene Expression (incl. Microarray and other genome-wide approaches)
Abstract Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans. To identify additional loci, we conducted meta-analysis of 15 genome-wide association studies for BMI (n > 32,000) and followed up top signals in 14 additional cohorts (n > 59,000). We strongly confirm FTO and MC4R and identify six additional loci (P < 5 x 10(-8)): TMEM18, KCTD15, GNPDA2, SH2B1, MTCH2 and NEGR1 (where a 45-kb deletion polymorphism is a candidate causal variant). Several of the likely causal genes are highly expressed or known to act in the central nervous system (CNS), emphasizing, as in rare monogenic forms of obesity, the role of the CNS in predisposition to obesity.
Keyword Genome-wide Association
Coronary-artery-disease
Common variants
Alcohol Dependence
Gene-expression
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ
Additional Notes Please note that Matthew Brown and Linda Bradbury are members of the Wellcome Trust Case Control Consortium

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Diamantina Institute Publications
 
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Created: Wed, 14 Apr 2010, 16:05:48 EST by Kylie Hengst on behalf of UQ Diamantina Institute