Relative abundance of full-length and truncated FOXP1 isoforms is associated with differential NF kappa B activity in Follicular Lymphoma

Green, Michael R., Gandhi, Maher K., Courtney, Mark J., Marlton, Paula and Griffiths, Lyn (2009) Relative abundance of full-length and truncated FOXP1 isoforms is associated with differential NF kappa B activity in Follicular Lymphoma. Leukemia Research, 33 12: 1699-1702. doi:10.1016/j.leukres.2009.05.004


Author Green, Michael R.
Gandhi, Maher K.
Courtney, Mark J.
Marlton, Paula
Griffiths, Lyn
Title Relative abundance of full-length and truncated FOXP1 isoforms is associated with differential NF kappa B activity in Follicular Lymphoma
Formatted title
Relative abundance of full-length and truncated FOXP1 isoforms is associated with differential NFκB activity in Follicular Lymphoma
Journal name Leukemia Research   Check publisher's open access policy
ISSN 0145-2126
1873-5835
Publication date 2009
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.leukres.2009.05.004
Volume 33
Issue 12
Start page 1699
End page 1702
Total pages 4
Place of publication Kidlington, Oxford, United Kingdom
Publisher Elsevier
Collection year 2010
Language eng
Abstract FOXP1 is a transcriptional repressor that has been proposed to repress the expression of some NFκB-responsive genes. Furthermore, truncated forms of FOXP1 have been associated with a subtype of Diffuse Large B-cell Lymphoma characterised by constitutive NFκB activity, indicating that they may inhibit this repression. We have shown that FL tumors have increased relative abundance of truncated FOXP1 isoforms and this is associated with increased expression of NFκB-associated genes. Our results provide strong evidence that relative FOXP1 isoform abundance is associated with NFκB activity in FL, and could potentially be used as a marker for this gene signature.
Keyword Non-Hodgkin's Lymphoma
Follicular Lymphoma
FOXP1
NFκB
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ
Additional Notes Published under Brief Communications

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Medicine Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 16 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 18 times in Scopus Article | Citations
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Created: Wed, 14 Apr 2010, 13:43:23 EST by Maree Knight on behalf of Medicine - Princess Alexandra Hospital