Is there more than one proctitis syndrome? A revisitation using data from the TROG 96.01 trial

Capp, Anne, Inostroza-Ponta, Mario, Bill, Dana, Moscato, Pablo, Lai, Chi, Christie, David, Lamb, David, Turner, Sandra, Joseph, David, Matthews, John, Atkinson, Chris, North, John, Poulsen, Michael, Spry, Nigel A., Tai, Keen-Hun, Wynne, Chris, Duchesne, Gillian, Steigler, Allison and Denham, James W. (2009) Is there more than one proctitis syndrome? A revisitation using data from the TROG 96.01 trial. Radiotherapy and Oncology, 90 3: 400-407. doi:10.1016/j.radonc.2008.09.019


Author Capp, Anne
Inostroza-Ponta, Mario
Bill, Dana
Moscato, Pablo
Lai, Chi
Christie, David
Lamb, David
Turner, Sandra
Joseph, David
Matthews, John
Atkinson, Chris
North, John
Poulsen, Michael
Spry, Nigel A.
Tai, Keen-Hun
Wynne, Chris
Duchesne, Gillian
Steigler, Allison
Denham, James W.
Title Is there more than one proctitis syndrome? A revisitation using data from the TROG 96.01 trial
Journal name Radiotherapy and Oncology   Check publisher's open access policy
ISSN 0167-8140
1879-0887
Publication date 2009-03
Year available 2008
Sub-type Article (original research)
DOI 10.1016/j.radonc.2008.09.019
Volume 90
Issue 3
Start page 400
End page 407
Total pages 8
Editor Dr J. Overgaard
Place of publication Shannon, Co. Clare, Ireland
Publisher Elsevier Ireland
Language eng
Subject 920102 Cancer and Related Disorders
111208 Radiation Therapy
Formatted abstract
Purpose:
We sought to categorize longitudinal radiation-induced rectal toxicity data obtained from men participating in a randomised controlled trial for locally advanced prostate cancer.

Materials and methods
:

Data from self-assessed questionnaires of rectal symptoms and clinician recorded remedial interventions were collected during the TROG 96.01 trial. In this trial, volunteers were randomised to radiation with or without neoadjuvant androgen deprivation. Characterization of longitudinal variations in symptom intensity was achieved using prevalence data. An integrated visualization and clustering approach based on memetic algorithms was used to define the compositions of symptom clusters occurring before, during and after radiation. The utility of the CTC grading system as a means of identifying specific injury profiles was evaluated using concordance analyses.

Results:
Seven well-defined clusters of rectal symptoms were present prior to treatment, 25 were seen immediately following radiation and 7 at years 1, 2 and 3 following radiation. CTC grading did not concord with degree of rectal ‘distress’ and ‘problems’ at all time points. Concordance was not improved by adding urgency to the CTC scale.

Conclusions:
The CTC scale has serious shortcomings. A powerful new technique for non-hierarchical clustering may contribute to the categorization of rectal toxicity data for genomic profiling studies and detailed patho-physiological studies.
Keyword Proctitis
CTC Scale
Radiation Rectal Toxicity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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Created: Wed, 14 Apr 2010, 12:38:17 EST by Fiona Mactaggart on behalf of Medicine - Princess Alexandra Hospital