Common variants at five new loci associated with early-onset inflammatory bowel disease.

Imielinski, M., Baldassano, R. N., Griffiths, A., Russell, R. K., Annese, V., Dubinsky, M., Kugathasan, S., Bradfield, J. P., Walters, T. D., et al, International IBD Genetics Consortium, Brown, Matthew A. and Bradbury, Linda (2009) Common variants at five new loci associated with early-onset inflammatory bowel disease.. Nature Genetics, 41 12: 1335-1340. doi:10.1038/ng.489


Author Imielinski, M.
Baldassano, R. N.
Griffiths, A.
Russell, R. K.
Annese, V.
Dubinsky, M.
Kugathasan, S.
Bradfield, J. P.
Walters, T. D.
et al
International IBD Genetics Consortium
Brown, Matthew A.
Bradbury, Linda
Title Common variants at five new loci associated with early-onset inflammatory bowel disease.
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
Publication date 2009-12
Year available 2009
Sub-type Article (original research)
DOI 10.1038/ng.489
Volume 41
Issue 12
Start page 1335
End page 1340
Total pages 6
Editor Axton, M.
Place of publication United States
Publisher Nature Publishing Gourp
Collection year 2010
Language eng
Subject C1
970106 Expanding Knowledge in the Biological Sciences
970111 Expanding Knowledge in the Medical and Health Sciences
920105 Digestive System Disorders
060408 Genomics
060405 Gene Expression (incl. Microarray and other genome-wide approaches)
Abstract The inflammatory bowel diseases (IBD) Crohn's disease and ulcerative colitis are common causes of morbidity in children and young adults in the western world. Here we report the results of a genome-wide association study in early-onset IBD involving 3,426 affected individuals and 11,963 genetically matched controls recruited through international collaborations in Europe and North America, thereby extending the results from a previous study of 1,011 individuals with early-onset IBD1. We have identified five new regions associated with early-onset IBD susceptibility, including 16p11 near the cytokine gene IL27 (rs8049439, P = 2.41 x 10(-9)), 22q12 (rs2412973, P = 1.55 x 10(-9)), 10q22 (rs1250550, P = 5.63 x 10(-9)), 2q37 (rs4676410, P = 3.64 x 10(-8)) and 19q13.11 (rs10500264, P = 4.26 x 10(-10)). Our scan also detected associations at 23 of 32 loci previously implicated in adult-onset Crohn's disease and at 8 of 17 loci implicated in adult-onset ulcerative colitis, highlighting the close pathogenetic relationship between early- and adult-onset IBD.
Keyword GENOME-WIDE ASSOCIATION
CROHNS-DISEASE
SUSCEPTIBILITY LOCI
SEQUENCE VARIANTS
GENE
EXPRESSION
CONTRIBUTE
AUTOPHAGY
MULTIPLE
HISTORY
Q-Index Code C1
Q-Index Status Confirmed Code
Additional Notes The Wellcome Trust Case Control Consortium are part of the International IBD Genetics Consortium. Please note that Matthew Brown and Linda Bradbury are members of the Wellcome Trust Case Control Consortium

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
UQ Diamantina Institute Publications
 
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Created: Wed, 14 Apr 2010, 12:13:36 EST by Kylie Hengst on behalf of UQ Diamantina Institute