New insights into the protective effect of manganese against oxidative stress

McEwan, Alastair G. (2009) New insights into the protective effect of manganese against oxidative stress. Molecular Microbiology, 72 4: 812-814. doi:10.1111/j.1365-2958.2009.06700.x


Author McEwan, Alastair G.
Title New insights into the protective effect of manganese against oxidative stress
Journal name Molecular Microbiology   Check publisher's open access policy
ISSN 0950-382X
1365-2958
Publication date 2009-05
Sub-type Editorial
DOI 10.1111/j.1365-2958.2009.06700.x
Volume 72
Issue 4
Start page 812
End page 814
Total pages 3
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2010
Language eng
Formatted abstract
Manganese has emerged as an important trace element in bacterial physiology. The correlation between manganese accumulation and resistance to oxidative stress has led to the suggestion that, in addition to a role as a prosthetic group in superoxide dismutase, manganese could exert its antioxidant effect via non-enzymatic redox reactions. The article by Anjem et al. in the current issue of Molecular Microbiology investigates the role of manganese ions in the defence against hydrogen peroxide in Escherichia coli. The results indicate that the redox activity of manganese is not linked to its protective effect. Instead, it is suggested that manganese replaces ferrous iron in enzymes that contain divalent cations at their active site. This enables the cell to avoid oxidative stress associated with iron release in the presence of hydrogen peroxide.
Q-Index Code CX
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Published under MicroCommentaries

Document type: Journal Article
Sub-type: Editorial
Collections: 2010 Higher Education Research Data Collection
School of Chemistry and Molecular Biosciences
 
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Citation counts: TR Web of Science Citation Count  Cited 19 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 19 times in Scopus Article | Citations
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Created: Wed, 14 Apr 2010, 10:14:28 EST by Jennifer Falknau on behalf of School of Chemistry & Molecular Biosciences