Blood cell manufacture: current methods and future challenges

Timmins, N.E. and Nielsen, L.K. (2009) Blood cell manufacture: current methods and future challenges. Trends in Biotechnology, 27 7: 415-422. doi:10.1016/j.tibtech.2009.03.008


Author Timmins, N.E.
Nielsen, L.K.
Title Blood cell manufacture: current methods and future challenges
Journal name Trends in Biotechnology   Check publisher's open access policy
ISSN 0167-7799
Publication date 2009-07
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.tibtech.2009.03.008
Volume 27
Issue 7
Start page 415
End page 422
Total pages 8
Editor Petra Gross
Place of publication United Kingdom
Publisher Elsevier Ltd, Trends Journals
Collection year 2010
Language eng
Subject C1
Abstract Blood transfusion depends on availability of donor material, and concerns over supply and safety have spurred development of methods to manufacture blood from stem cells. Current methods could theoretically yield therapeutic doses of red blood cells (RBCs) and platelets. However, due to the very large number of cells required to have any impact on supply (currently 10(19) RBC/year in the US), realization of routine manufacture faces significant challenges. Current yields are orders of magnitude too low for production of meaningful quantities, and the physical scale of the problem is a challenge in itself. We discuss these challenges in relation to current methods and how it might be possible to realize limited 'blood pharming' of neutrophils in the near future. (C)2009 Elsevier Ltd.
Keyword EX-VIVO EXPANSION
HEMATOPOIETIC STEM-CELLS
TUMOR-INFILTRATING LYMPHOCYTES
MOBILIZED PERIPHERAL-BLOOD
HOLLOW-FIBER BIOREACTORS
MARROW PROGENITOR CELLS
LARGE-SCALE GENERATION
CORD BLOOD
BONE-MARROW
IN-VITRO
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
Australian Institute for Bioengineering and Nanotechnology Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 44 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 12 Apr 2010, 15:31:51 EST by Sharon Paterson on behalf of Aust Institute for Bioengineering & Nanotechnology