Intestinal barrier dysfunction in inflammatory bowel diseases

McGuckin, Michael A., Eri, Rajaraman, Simms, Lisa A., Florin, Timothy H. J. and Radford-Smith, Graham (2009) Intestinal barrier dysfunction in inflammatory bowel diseases. Inflammatory Bowel Diseases, 15 1: 100-113. doi:10.1002/ibd.20539

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
IntestinalBarrierDysfunctionInIBD.pdf IntestinalBarrierDysfunctionInIBD.pdf application/pdf 335.91KB 604

Author McGuckin, Michael A.
Eri, Rajaraman
Simms, Lisa A.
Florin, Timothy H. J.
Radford-Smith, Graham
Title Intestinal barrier dysfunction in inflammatory bowel diseases
Journal name Inflammatory Bowel Diseases   Check publisher's open access policy
ISSN 1536-4844
Publication date 2009-01
Year available 2008
Sub-type Article (original research)
DOI 10.1002/ibd.20539
Open Access Status File (Author Post-print)
Volume 15
Issue 1
Start page 100
End page 113
Total pages 14
Place of publication Hoboken, NJ, USA
Publisher John Wiley & Sons Inc
Language eng
Subject 110307 Gastroenterology and Hepatology
920105 Digestive System Disorders
Abstract The etiology of human inflammatory bowel diseases (IBDs) is believed to involve inappropriate host responses to the complex commensal microbial flora in the gut, although an altered commensal flora is not completely excluded. A multifunctional cellular and secreted barrier separates the microbial flora from host tissues. Altered function of this barrier remains a major largely unexplored pathway to IBD. Although there is evidence of barrier dysfunction in IBD, it remains unclear whether this is a primary contributor to disease or a consequence of mucosal inflammation. Recent evidence from animal models demonstrating that genetic defects restricted to the epithelium can initiate intestinal inflammation in the presence of normal underlying immunity has refocused attention on epithelial dysfunction in IBD. We review the components of the secreted and cellular barrier, their regulation, including interactions with underlying innate and adaptive immunity, evidence from animal models of the barrier's role in preventing intestinal inflammation, and evidence of barrier dysfunction in both Crohn's disease and ulcerative colitis. (Inflamm Bowel Dis 2008)
Keyword Inflammatory Bowel Diseases/*metabolism
mucosal barrier dysfunction
intestinal inflammation
epithelial dysfunction
inflammatory bowel disease
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Student Publications
School of Medicine Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 203 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 227 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Mon, 12 Apr 2010, 14:13:08 EST by Mary Herwig on behalf of Medicine - Mater Hospital