Enhanced insulin sensitivity in mice lacking ganglioside GM3

Yamashita, Tadashi, Hashiramoto, Akira, Haluzik, Martin, Mizukami, Hiroki, Beck, Shoshannah and et al. (2003) Enhanced insulin sensitivity in mice lacking ganglioside GM3. Proceedings of the National Academy of Sciences of the United States of America, 100 6: 3445-3449. doi:10.1073/pnas.0635898100


Author Yamashita, Tadashi
Hashiramoto, Akira
Haluzik, Martin
Mizukami, Hiroki
Beck, Shoshannah
et al.
Title Enhanced insulin sensitivity in mice lacking ganglioside GM3
Journal name Proceedings of the National Academy of Sciences of the United States of America   Check publisher's open access policy
ISSN 0027-8424
1091-6490
Publication date 2003-03-18
Sub-type Article (original research)
DOI 10.1073/pnas.0635898100
Open Access Status Not Open Access
Volume 100
Issue 6
Start page 3445
End page 3449
Total pages 5
Editor Nicholas R. Cozzarelli
Place of publication Washington, DC, U.S.A.
Publisher National Academy of Sciences of the U.S.
Language eng
Subject 0601 Biochemistry and Cell Biology
Formatted abstract
Gangliosides are sialic acid-containing glycosphingolipids that are present on all mammalian plasma membranes where they participate in recognition and signaling activities. We have established mutant mice that lack GM3 synthase (CMP-NeuAc:lactosylceramide α2,3-sialyltransferase; EC 2.4.99.-). These mutant mice were unable to synthesize GM3 ganglioside, a simple and widely distributed glycosphingolipid. The mutant mice were viable and appeared without major abnormalities but showed a heightened sensitivity to insulin. A basis for the increased insulin sensitivity in the mutant mice was found to be enhanced insulin receptor phosphorylation in skeletal muscle. Importantly, the mutant mice were protected from high-fat diet-induced insulin resistance. Our results show that GM3 ganglioside is a negative regulator of insulin signaling, making it a potential therapeutic target in type 2 diabetes.
Keyword Lipid rafts
Pathogenesis
Association
Resistance
Caveolae
Receptor
Muscle
Cells
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Mon, 12 Apr 2010, 12:09:03 EST by June Temby on behalf of Faculty Of Health Sciences