Experimental validation studies on a multi-dimensional and multi-scale population balance model of batch granulation

Poon, J.M., Ramachandran, R., Sanders, C.F., Glaser, T., Immanuel, C.D., Doyle, F.J., Litster, J.D., Stepanek, F., Wang, F.Y. and Cameron, I.T. (2009) Experimental validation studies on a multi-dimensional and multi-scale population balance model of batch granulation. Chemical Engineering Science, 64 4: 775-786. doi:10.1016/j.ces.2008.08.037


Author Poon, J.M.
Ramachandran, R.
Sanders, C.F.
Glaser, T.
Immanuel, C.D.
Doyle, F.J.
Litster, J.D.
Stepanek, F.
Wang, F.Y.
Cameron, I.T.
Title Experimental validation studies on a multi-dimensional and multi-scale population balance model of batch granulation
Journal name Chemical Engineering Science   Check publisher's open access policy
ISSN 0009-2509
Publication date 2009-01-01
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.ces.2008.08.037
Volume 64
Issue 4
Start page 775
End page 786
Total pages 12
Editor Bell, A.
Place of publication United Kingdom
Publisher Pergamon
Collection year 2010
Language eng
Subject C1
090406 Powder and Particle Technology
860699 Industrial Chemicals and Related Products not elsewhere classified
Abstract In this study, a dynamic model is presented for the granulation process, employing a three-dimensional Population balance framework. As a first attempt to account for the multi-scale character of the process, the nucleation and aggregation kernels used in the population balance model are derived using mechanistic representations of the underlying particle physics such as wetting kinetics and energy dissipation effects. Thus, the fundamental properties of the powder and the liquid were used as parameters in the model to predict the granulator dynamics and granule properties. The population balance model is validated against experimental data from a calcite/PVOH-H2O recipe obtained using a lab-scale drum granulator for granule size, fractional binder content and porosity. A reasonably good agreement between experimental and simulation results were obtained for the granule size distribution under different experimental conditions. In addition, accurate model predictions were made for the evolution of the average properties (i.e., size, fractional binder content and porosity) for various operating conditions.
Keyword multi-dimensional, balance model
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Chemical Engineering Publications
 
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Created: Sun, 11 Apr 2010, 10:13:29 EST by Vicki Thompson on behalf of School of Chemical Engineering