T cells from patients with Guillain-Barre syndrome produce interferon-gamma in response to stimulation with the ganglioside GM1

McCombe, P. A. and Csurhes, P. A. (2010) T cells from patients with Guillain-Barre syndrome produce interferon-gamma in response to stimulation with the ganglioside GM1. Journal of Clinical Neuroscience, 17 4: 537-538. doi:10.1016/j.jocn.2009.07.096

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Author McCombe, P. A.
Csurhes, P. A.
Title T cells from patients with Guillain-Barre syndrome produce interferon-gamma in response to stimulation with the ganglioside GM1
Journal name Journal of Clinical Neuroscience   Check publisher's open access policy
ISSN 0967-5868
1532-2653
Publication date 2010-04
Sub-type Article (original research)
DOI 10.1016/j.jocn.2009.07.096
Volume 17
Issue 4
Start page 537
End page 538
Total pages 2
Editor Gillian Griffith
Place of publication South Melbourne, Vic., Australia
Publisher Churchill Livingstone
Collection year 2011
Language eng
Formatted abstract
Guillain-Barré syndrome (GBS) is an acquired demyelinating neuropathy, characterized by infiltration of peripheral nerves with macrophages and T cells. There have been reports of antibodies to glycolipids in GBS. We have previously found T cell reactivity to glycolipids in patients with the demyelinating form of GBS. This study was performed to characterize the cytokines produced by these T cells. Peripheral blood lymphocytes from patients with GBS, chronic inflammatory demyelinating polyradiculoneuropathy, healthy control patients and other neuropathies were incubated with the ganglioside GM1 and transferred to enzyme-linked immunospot plates. The average number per well of spot-forming cells (SFC) in the absence of antigen was counted. The average spontaneous SFC number was subtracted from the average SFC number in the presence of GM1, to produce a corrected SFC. There was significantly increased production of interferon-gamma but not interleukin-5 in response to stimulation with the ganglioside GM1. This could indicate that SFC have a role in pathogenesis of disease.
© 2009 Elsevier Ltd. All rights reserved.
Keyword Neuropathy
Ganglioside
T lymphocyte
Guillain-Barre syndrome
Inflammatory demyelinating polyradiculoneuropathy
Peripheral blood
Myelin proteins
Reactivity
P2
P0
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Faculty of Health and Behavioural Sciences -- Publications
UQ Centre for Clinical Research Publications
Official 2011 Collection
 
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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Created: Sun, 11 Apr 2010, 00:03:56 EST