The Anti-Inflammatory Agent N-Acetyl Cysteine Exacerbates Endotoxin-Induced Hypoxemia and Hypotension and Induces Polycythemia in the Ovine Fetus

Probyn, Megan E., Cock, Megan L., Duncan, Jhodie R., Tolcos, Mary, Hale, Nadia, Shields, Amy, Rees, Sandra and Harding, Richard (2010) The Anti-Inflammatory Agent N-Acetyl Cysteine Exacerbates Endotoxin-Induced Hypoxemia and Hypotension and Induces Polycythemia in the Ovine Fetus. Neonatology, 98 2: 118-127. doi:10.1159/000280385


Author Probyn, Megan E.
Cock, Megan L.
Duncan, Jhodie R.
Tolcos, Mary
Hale, Nadia
Shields, Amy
Rees, Sandra
Harding, Richard
Title The Anti-Inflammatory Agent N-Acetyl Cysteine Exacerbates Endotoxin-Induced Hypoxemia and Hypotension and Induces Polycythemia in the Ovine Fetus
Journal name Neonatology   Check publisher's open access policy
ISSN 1661-7800
Publication date 2010-02
Year available 2010
Sub-type Article (original research)
DOI 10.1159/000280385
Volume 98
Issue 2
Start page 118
End page 127
Total pages 10
Editor C Speer
H L Halliday
Place of publication Switzerland
Publisher S. Karger AG
Collection year 2011
Language eng
Subject C1
920114 Reproductive System and Disorders
111401 Foetal Development and Medicine
Abstract Background: Lipopolysaccharide (LPS) delivered acutely to the ovine fetus induces cerebral white matter injury and brain inflammation. N-acetyl cysteine (NAC) is potentially neuroprotective as it blocks the production of inflammatory cytokines and increases glutathione levels; however, it is unknown whether NAC affects the physiological status of the fetus already exposed to an inflammatory environment. Objectives: Our objective was to determine whether NAC influences the physiological effects of LPS exposure in the ovine fetus. Methods: Catheterized fetal sheep underwent one of four treatments (saline, n = 6; LPS, n = 6; LPS + NAC, n = 6; NAC, n = 3) on 5 consecutive days from 95 days of gestation (term similar to 147 days). Fetal arterial pressure and heart rate were recorded and blood samples collected. Results: LPS administration resulted in fetal hypoxemia and hypotension; simultaneous treatment with NAC exacerbated these effects and induced polycythemia. NAC treatment alone had no effect on the fetus. Conclusion: In the presence of LPS, NAC compromises fetal physiological status, suggesting that it may not be a suitable antenatal treatment for a fetus with evidence of inflammation. Copyright (C) 2010 S. Karger AG, Basel
Keyword Endotoxin
Fetal blood pressure
Hypotension
Hypoxemia
N-acetyl cysteine
Polycythemia
Tumor necrosis factor-alpha
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2011 Collection
School of Biomedical Sciences Publications
 
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Created: Sun, 11 Apr 2010, 00:01:56 EST