Association of novel genetic loci with circulating fibrinogen levels: A genome-wide association study in 6 population-based cohorts

Dehghan, Abbas, Yang, Qiong, Peters, Annette, Basu, Saonli, Bis, Joshua, Rudnicka, Alicja, Kavousi, Maryam, Chen, Ming-Huei, Baumert, Jens, Lowe, Gordon, et al, Wellcome Trust Case Control Consortium, Brown, Matthew and Bradbury, Linda (2009) Association of novel genetic loci with circulating fibrinogen levels: A genome-wide association study in 6 population-based cohorts. Circulation: Cardiovascular Genetics, 2 2: 125-133. doi:10.1161/CIRCGENETICS.108.825224


Author Dehghan, Abbas
Yang, Qiong
Peters, Annette
Basu, Saonli
Bis, Joshua
Rudnicka, Alicja
Kavousi, Maryam
Chen, Ming-Huei
Baumert, Jens
Lowe, Gordon
et al
Wellcome Trust Case Control Consortium
Brown, Matthew
Bradbury, Linda
Title Association of novel genetic loci with circulating fibrinogen levels: A genome-wide association study in 6 population-based cohorts
Journal name Circulation: Cardiovascular Genetics   Check publisher's open access policy
ISSN 1942-325X
Publication date 2009-04-01
Year available 2009
Sub-type Article (original research)
DOI 10.1161/CIRCGENETICS.108.825224
Volume 2
Issue 2
Start page 125
End page 133
Total pages 9
Editor Ramachandran Vasan
Place of publication United States
Publisher Lippincott Williams & Wilkins
Collection year 2010
Language eng
Subject C1
970106 Expanding Knowledge in the Biological Sciences
970111 Expanding Knowledge in the Medical and Health Sciences
920101 Blood Disorders
060405 Gene Expression (incl. Microarray and other genome-wide approaches)
110299 Cardiovascular Medicine and Haematology not elsewhere classified
Abstract Background— Fibrinogen is both central to blood coagulation and an acute-phase reactant. We aimed to identify common variants influencing circulation fibrinogen levels. Methods and Results— We conducted a genome-wide association analysis on 6 population-based studies, the Rotterdam Study, the Framingham Heart Study, the Cardiovascular Health Study, the Atherosclerosis Risk in Communities Study, the Monitoring of Trends and Determinants in Cardiovascular Disease/KORA Augsburg Study, and the British 1958 Birth Cohort Study, including 22 096 participants of European ancestry. Four loci were marked by 1 or more single-nucleotide polymorphisms that demonstrated genome-wide significance (P<5.0x10–8). These included a single-nucleotide polymorphism located in the fibrinogen β chain (FGB) gene and 3 single-nucleotide polymorphisms representing newly identified loci. The high-signal single-nucleotide polymorphisms were rs1800789 in exon 7 of FGB (P=1.8x10–30), rs2522056 downstream from the interferon regulatory factor 1 (IRF1) gene (P=1.3x10–15), rs511154 within intron 1 of the propionyl coenzyme A carboxylase (PCCB) gene (P=5.9x10–10), and rs1539019 on the NLR family pyrin domain containing 3 isoforms (NLRP3) gene (P=1.04x10–8). Conclusions— Our findings highlight biological pathways that may be important in regulation of inflammation underlying cardiovascular disease.
Keyword Genome-wide
Fibrinogen
Genes
Meta-analysis
Q-Index Code C1
Q-Index Status Confirmed Code
Additional Notes Matthew Brown and Linda Bradbury are part of the Wellcome Trust Case Control Consortium

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
UQ Diamantina Institute Publications
 
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Created: Sat, 10 Apr 2010, 01:19:02 EST by Sarah Macaione on behalf of UQ Diamantina Institute