Role of statins in diabetes complications

Martin, Jennifer H., Mangiafico, Salvatore and Kelly, Darren J. (2009) Role of statins in diabetes complications. Current Diabetes Reviews, 5 3: 165-170. doi:10.2174/157339909788920901

Attached Files (Some files may be inaccessible until you login with your UQ eSpace credentials)
Name Description MIMEType Size Downloads
UQ202050_fulltext.pdf UQ202050_fulltext.pdf application/pdf 3.43MB 1

Author Martin, Jennifer H.
Mangiafico, Salvatore
Kelly, Darren J.
Title Role of statins in diabetes complications
Journal name Current Diabetes Reviews   Check publisher's open access policy
ISSN 1573-3998
Publication date 2009-08
Sub-type Critical review of research, literature review, critical commentary
DOI 10.2174/157339909788920901
Volume 5
Issue 3
Start page 165
End page 170
Total pages 6
Place of publication The Netherlands
Publisher Bentham Science Publishers
Language eng
Subject 1103 Clinical Sciences
Formatted abstract
Diabetes is one of the major causes of morbidity and mortality in the Western world and it currently affects 35 million people in the US alone. Cardiovascular and renal complications of diabetes, Type I and II, account for much of this morbidity, and are now known to be the end result of a complex interplay of pathophysiological processes. These include haemodynamic and metabolic abnormalities such as endothelial dysfunction, inflammation, vasoconstriction, oxidation and fibrosis. For some time it has been difficult to elucidate whether these processes and subsequent dysfunction in organs such as the heart and kidney is due to processes that often coexist with diabetes, such as hypertension. However, it is now clear that there is a distinct pro-inflammatory and pro-fibrotic state in diabetes, which may in addition be complicated by synergistic disease processes. The use of statins in diabetes has been of interest for a while due to the known effect of statins on inflammatory and fibrotic pathways. This review covers the clinical evidence for the use of statins in diabetes, the major known pathophysiological processes that occur in diabetic organ disease and discusses the known and putative effects of statins on these pathways. It concludes with a brief discussion of some early and yet unpublished work regarding the addition of statin therapy to angiotensin inhibition therapy in diabetic disease.
© 2009 Bentham Science Publishers Ltd.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
Version Filter Type
Citation counts: Scopus Citation Count Cited 6 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Thu, 08 Apr 2010, 12:53:02 EST by Jon Swabey on behalf of Faculty Of Health Sciences