A retrospective review of burn dressings on a porcine burn model

Wang, Xue-Qing, Kravchuk, Olena and Kimble, Roy M. (2010) A retrospective review of burn dressings on a porcine burn model. Burns, 36 5: 680-687. doi:10.1016/j.burns.2009.06.200

Author Wang, Xue-Qing
Kravchuk, Olena
Kimble, Roy M.
Title A retrospective review of burn dressings on a porcine burn model
Journal name Burns   Check publisher's open access policy
ISSN 0305-4179
Publication date 2010-08
Year available 2009
Sub-type Article (original research)
DOI 10.1016/j.burns.2009.06.200
Volume 36
Issue 5
Start page 680
End page 687
Total pages 8
Editor S. Wolf
Place of publication Oxford, United Kingdom
Publisher Elsevier Science
Collection year 2011
Language eng
Subject C1
11 Medical and Health Sciences
0707 Veterinary Sciences
Formatted abstract
This is a study to compare wound healing among three types of dressings on a porcine model with deep-dermal-partial-thickness burns. The burns in this study were from eight animal trials conducted in the past for other purposes and only burns with a uniform pale appearance that had served as controls in original experiments were selected. In total, there were 57 burns in 33 pigs, using one of following three dressings: Acticoat (Silver) (3 trials), Jelonet (Gauze) (3 trials), and Solosite Gel/Jelonet (Gel/Gauze) (2 trials). The wound healing assessments included wound re-epithelialisation during a 6-week period, clinical and histological scar assessments at week 6 after burn. Of all wound healing/scar assessments, only re-epithelialisation showed statistical difference between dressings. Earlier re-epithelialisation was observed in Gel/Gauze dressings compared to Silver and/or Gauze dressings. However, this study revealed huge variation in wound healing outcome between 3 trials within both Silver and/or Gauze dressings, supported by significant differences on re-epithelialisation, clinical and histological scar measurements. In addition, it was found that larger animals healed better than smaller ones, based on weights from 21 pigs. Of all dressings, Silver delivers the best protection for wound colonization/infection. Wound colonization/infection was found to confine wound healing and lead to thinner RND in scars. From this study, we cannot find enough evidence to suggest the beneficial effect of one dressing(s) over others on burn wound healing outcome on a porcine model with small deep-dermal-partial-thickness burns with a relative small sample size.
© 2009 Elsevier Ltd
Keyword Burn injury
Burn wound healing
Porcine burn model
Burn dressing
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes Available online 27 October 2009

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
2010 Higher Education Research Data Collection
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 9 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 13 times in Scopus Article | Citations
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Created: Thu, 08 Apr 2010, 11:23:34 EST by Fiona Mactaggart on behalf of Paediatrics & Child Health - RBWH