Layered double hydroxide nanoparticles in gene and drug delivery

Ladewig, K., Xu, Z.P. and Lu, G.Q. (2009) Layered double hydroxide nanoparticles in gene and drug delivery. Expert Opinion on Drug Delivery, 6 9: 907-922. doi:10.1517/17425240903130585

Author Ladewig, K.
Xu, Z.P.
Lu, G.Q.
Title Layered double hydroxide nanoparticles in gene and drug delivery
Journal name Expert Opinion on Drug Delivery   Check publisher's open access policy
ISSN 1742-5247
Publication date 2009-09
Year available 2009
Sub-type Article (original research)
DOI 10.1517/17425240903130585
Volume 6
Issue 9
Start page 907
End page 922
Total pages 16
Editor Joris Roulleau
Kimber Jest
Place of publication United Kingdom
Publisher Informa Healthcare UK
Collection year 2010
Language eng
Subject C1
970109 Expanding Knowledge in Engineering
100708 Nanomaterials
Abstract Layered double hydroxides (LDHs) have been known for many decades as catalyst and ceramic precursors, traps for anionic pollutants, catalysts and additives for polymers, but their successful synthesis on the nanometer scale a few years ago opened up a whole new field for their application in nanomedicine. The delivery of drugs and other therapeutic/bioactive molecules (e.g., peptides, proteins, nucleic acids) to mammalian cells is an area of research that is of tremendous importance to medicine and provides manifold applications for any new developments in the area of nanotechnology. Among the many different nanoparticles that have been shown to facilitate gene and/or drug delivery, LDH nanoparticles have attracted particular attention owing to their many desirable properties. This review aims to report recent progress in gene and drug delivery using LDH nanoparticles. It summarizes the advantages and disadvantages of using LDH nanoparticles as carriers for nucleic acids and drugs against the general background of bottlenecks that are encountered by cellular delivery systems. It describes further the models that have been proposed for the internalization of LDH nanoparticles into cells so far and discusses the intracellular fate of the particles and their cargo. The authors offer some remarks on how this field of research will progress in the near future and which challenges need to be overcome before LDH nanoparticles can be used in a clinical setting. (C)2009 Informa UK Ltd
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
Australian Institute for Bioengineering and Nanotechnology Publications
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Citation counts: TR Web of Science Citation Count  Cited 97 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 07 Apr 2010, 16:52:23 EST by Sharon Paterson on behalf of Aust Institute for Bioengineering & Nanotechnology