Acute viral bronchiolitis in children - a very common condition with few therapeutic options

Wainwright, Claire (2009) Acute viral bronchiolitis in children - a very common condition with few therapeutic options. Paediatric Respiratory Reviews, 11 1: 39-45. doi:10.1016/j.prrv.2009.10.001

Author Wainwright, Claire
Title Acute viral bronchiolitis in children - a very common condition with few therapeutic options
Journal name Paediatric Respiratory Reviews   Check publisher's open access policy
ISSN 1526-0542
Publication date 2009
Sub-type Article (original research)
DOI 10.1016/j.prrv.2009.10.001
Volume 11
Issue 1
Start page 39
End page 45
Total pages 7
Editor E. Eber
Place of publication United Kingdom
Publisher Elsevier
Collection year 2010
Language eng
Subject C1
920501 Child Health
920115 Respiratory System and Diseases (incl. Asthma)
Formatted abstract
Acute viral bronchiolitis remains a cause of substantial morbidity and health care costs in young infants. It is the most common lower respiratory tract condition and most common reason for admission to hospital in infants. Many respiratory viruses have been associated with acute viral bronchiolitis although respiratory syncytial virus (RSV) remains the most frequently identified virus. Most infants have a mild self limiting illness while others have more severe illness and require hospital admission and some will need ventilatory support. Differences in innate immune function in response to the respiratory viral insult as well as differences in the geometry of the airways may explain some of the variability in clinical pattern. Young age and history of prematurity remain the most important risk factors although male gender, indigenous status, exposure to tobacco smoke, poor socioeconomic factors and associated comorbidities such as chronic lung disease and congenital heart disease increase the risks of more severe illness. Supportive therapy remains the major treatment option as no specific treatments to date have been shown to provide clinically important benefits except for inhaled hypertonic saline. Prophylaxis of high risk infants with palivizumab should be considered although the cost effectiveness is still unclear.
Many questions remain regarding optimal management approaches for infants requiring hospitalisation with bronchiolitis including use of nasogastric feeding, the optimal role of supplemental oxygen, optimal use of hypertonic saline and the role of combinations of therapies, the use of heliox or modern physiotherapy approaches.
Keyword Bronchiolitis
Respiratory Syncytial Virus (RSV)
Viral Respiratory Infection
Innate Immune Response
Q-Index Code C1
Q-Index Status Confirmed Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
School of Medicine Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 45 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 51 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Wed, 07 Apr 2010, 14:33:04 EST by Fiona Mactaggart on behalf of Medicine - Princess Alexandra Hospital