Alveolar macrophages and the CC chemokines are increased in children with cystic fibrosis

Brennan, S., Sly, P. D., Gangell, C. L., Sturges, N., Winfield, K., Wikstrom, M., Gard, S. and Upham, J. W. (2009) Alveolar macrophages and the CC chemokines are increased in children with cystic fibrosis. The European Respiratory Journal, 34 3: 655-661. doi:10.1183/09031936.00178508

Author Brennan, S.
Sly, P. D.
Gangell, C. L.
Sturges, N.
Winfield, K.
Wikstrom, M.
Gard, S.
Upham, J. W.
Title Alveolar macrophages and the CC chemokines are increased in children with cystic fibrosis
Journal name The European Respiratory Journal   Check publisher's open access policy
ISSN 0903-1936
Publication date 2009-09-01
Sub-type Article (original research)
DOI 10.1183/09031936.00178508
Volume 34
Issue 3
Start page 655
End page 661
Total pages 7
Place of publication Lausanne, Switzerland
Publisher European Respiratory Society
Collection year 2010
Language eng
Formatted abstract
Airway inflammation is an important component of cystic fibrosis (CF) lung disease. We sought to determine whether alveolar macrophages were involved in early CF lung disease.

Children with CF (median age 3.1 yrs) participated in a surveillance programme that included annual bronchoalveolar lavage (BAL). Control samples were obtained from non-CF children (median age 3.1 yrs; n = 24) investigated for persistent respiratory symptoms.

Pulmonary infection was detected in 31% (16 out of 51) and 38% (nine out of 24) of children from the CF and non-CF groups, respectively. Alveolar macrophages in BAL were increased in CF compared with non-CF in the absence of infection (223x103 versus 85x103 cells·mL–1; p = 0.001) and were associated with elevations in the CC chemokines (macrophage inflammatory protein (MIP)-3 (chemokine (C-C motif) ligand (CCL)20; 355.8 versus 46.0 pg·mL–1; p<0.001), monocyte chemotactic protein-1 (CCL2; 263.5 versus 25.3 pg·mL–1; p<0.001), MIP-1 (CCL3; 38.2 versus 4.9 pg·mL–1; p<0.001) and MIP-1β (CCL4; 326.6 versus 27.5 pg·mL–1; p<0.001)). Total cell counts and neutrophil numbers increased in the presence of infection; however, there was no additional effect of CF.

Alveolar macrophages and CC chemokines are elevated in the lungs in young children with CF even in the absence of pulmonary infection. Longitudinal studies are required to determine the clinical relevance of these findings.
Keyword Cystic fibrosis
Alveolar macrophage
Pulmonary infection
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: 2010 Higher Education Research Data Collection
ERA 2012 Admin Only
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 27 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 07 Apr 2010, 12:07:28 EST by Fiona Mactaggart on behalf of Medicine - Princess Alexandra Hospital