Clinical significance of Mycobacterium asiaticum isolates in Queensland, Australia

Grech, Miriam, Carter, Robyn and Thomson, Rachel (2010) Clinical significance of Mycobacterium asiaticum isolates in Queensland, Australia. Journal of Clinical Microbiology, 48 1: 162-167. doi:10.1128/JCM.01602-09

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Author Grech, Miriam
Carter, Robyn
Thomson, Rachel
Title Clinical significance of Mycobacterium asiaticum isolates in Queensland, Australia
Formatted title
Clinical significance of Mycobacterium asiaticum isolates in Queensland, Australia
Journal name Journal of Clinical Microbiology   Check publisher's open access policy
ISSN 1098-660X
Publication date 2010-01
Sub-type Article (original research)
DOI 10.1128/JCM.01602-09
Open Access Status File (Publisher version)
Volume 48
Issue 1
Start page 162
End page 167
Total pages 6
Place of publication Washington, DC, United States
Publisher American Society for Microbioloby
Collection year 2011
Language eng
Formatted abstract
Mycobacterium asiaticum was first reported as a cause of human disease in 1982, with only a few cases in the literature to date. This study aims to review the clinical significance of M. asiaticum isolates in Queensland, Australia. A retrospective review (1989 to 2008) of patients with M. asiaticum isolates was conducted. Data were
collected through the Queensland TB Control Centre database. Disease was defined in accordance with the American Thoracic Society criteria. Twenty-four patients (13 female) had a positive culture of M. asiaticum, many residing around the Tropic of Capricorn. M. asiaticum was responsible for pulmonary disease (n =  2),
childhood lymphadenitis (n = 1), olecranon bursitis (n = 1), 6 cases of possible pulmonary disease, and 2 possible wound infections. Chronic lung disease was a risk factor for pulmonary infection, and wounds/lacerations were a risk factor for extrapulmonary disease. Extrapulmonary disease responded to local measures.
Pulmonary disease responded to ethambutol-isoniazid-rifampin plus pyrazinamide for the first 2 months in one patient, and amikacin-azithromycin-minocycline in another patient. While M. asiaticum is rare in Queensland, there appears to be an environmental niche. Although often a colonizer, it can be a cause of pulmonary and extrapulmonary disease. Treatment of pulmonary disease remains challenging. Extrapulmonary disease does not mandate specific nontuberculous mycobacterium (NTM) treatment.
Copyright © 2010, American Society for Microbiology. All Rights Reserved.
Keyword Human Diseases
Clinical Significance
Extrapulmonary Disease
Nontuberculosis Mycobacteria
Mycobacterium asiaticum
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Medicine Publications
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Citation counts: TR Web of Science Citation Count  Cited 4 times in Thomson Reuters Web of Science Article | Citations
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Created: Wed, 07 Apr 2010, 10:15:08 EST by Fiona Mactaggart on behalf of Medicine - Princess Alexandra Hospital