Mechanisms of transmurally varying myocyte electromechanics in an integrated computational model

Campbell, Stuart G., Flaim, Sarah N., Leem, Chae H. and McCulloch, Andrew D. (2008) Mechanisms of transmurally varying myocyte electromechanics in an integrated computational model. Philosophical Transactions of the Royal Society of London. Series A: Mathematical Physical and Engineering Sciences, 366 1879: 3361-3380. doi:10.1098/rsta.2008.0088


Author Campbell, Stuart G.
Flaim, Sarah N.
Leem, Chae H.
McCulloch, Andrew D.
Title Mechanisms of transmurally varying myocyte electromechanics in an integrated computational model
Journal name Philosophical Transactions of the Royal Society of London. Series A: Mathematical Physical and Engineering Sciences   Check publisher's open access policy
ISSN 1364-503X
Publication date 2008-09
Sub-type Article (original research)
DOI 10.1098/rsta.2008.0088
Volume 366
Issue 1879
Start page 3361
End page 3380
Total pages 20
Place of publication London, U.K.
Publisher Royal Society of London
Language eng
Subject 1103 Clinical Sciences
Abstract The mechanical properties of myocardium vary across the transmural aspect of the left ventricular wall. Some of these functional heterogeneities may be related to differences in excitation–contraction coupling characteristics that have been observed in cells isolated from the epicardial, mid-myocardial and endocardial regions of the left ventricle of many species, including canine. Integrative models of coupled myocyte electromechanics are reviewed and used here to investigate sources of heterogeneous electromechanical behaviour in these cells. The simulations (i) illustrate a previously unrecognized role of the transient outward potassium current in mechanical function and (ii) suggest that there may also exist additional heterogeneities affecting crossbridge cycling rates in cells from different transmural regions.
Keyword Cardiac electromechanics
Computational modelling
Transmural heterogeneity
Q-Index Code C1
Q-Index Status Provisional Code

Document type: Journal Article
Sub-type: Article (original research)
Collections: Excellence in Research Australia (ERA) - Collection
School of Medicine Publications
 
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Created: Tue, 06 Apr 2010, 15:27:22 EST by Ms May Balasaize on behalf of Faculty Of Health Sciences